02130nas a2200265 4500008004100000245009500041210006900136260001700205300001200222490000700234520123800241653001901479653001601498653001401514100002901528700003301557700003001590700003301620700002901653700002901682700002801711700003001739700003301769856006201802 2020 eng d00aAcute Toxicity and Cytogenotoxicity of Yangambin Isolated from Ocotea duckei Vattimo‑Gil0 aAcute Toxicity and Cytogenotoxicity of Yangambin Isolated from O cJanuary 2021 a444-4490 v123 a

Background: Yangambin, a lignan isolated from Ocotea duckei leaves, has been reported to have antitumor, anxiolytic, hypotensive, and leishmanicidal activity, but there is little information on toxicity. Objective: The aim of this study was to investigate the acute toxicity of yangambin in mice, and cytotoxicity and genotoxicity through the Allium cepa assay. Materials and Methods: The yanganbin at a dose of 2000 mg/kg was orally administered once to mice to investigate acute toxicity, and meristem of the roots of Allium cepa was used to determine inhibition of root growth (root length) and mitotic index. Results: Yangambin did not cause hemolysis in sheep erythrocytes at concentrations of 12.5, 25, and 50 µg/mL, and did not show genotoxic changes in root meristem cells of Allium cepa at the same concentrations. In the acute toxicity study in Swiss mice at a dose of 2000 mg/kg, there were no apparent clinical signs or any behavioral changes and no deaths. Conclusion: Therefore, yangambin appears to a promising active compound for future pharmacological studies. 

10aAcute toxicity10aAllium cepa10aLauraceae1 aCastro, Maria, Isabel de1 ade Lucena, Marta, Gerusa Soa1 aSilva, Camilla, Vila Nova1 aXavier, Yhasminie, Karine da1 aFilho, José, Maria Barb1 aTeles, Maria, Madalena R1 aPeixoto, Laisla, Rangel1 ade Souza, Ivone, Antônia1 ada Silva, Eliete, Cavalcanti uhttps://www.phcogres.com/article/2020/12/4/104103prpr7320