02554nas a2200265 4500008004100000245008400041210006900125260001400194300001400208490000700222520171700229653003101946653001301977653001301990653003802003100002202041700002602063700002302089700002902112700002102141700002002162700002102182700001902203856006602222 2025 eng d00aXylopia aethiopica Fruit Macerate Inhibits Carrageenan-induced Pleurisy in Rats0 aXylopia aethiopica Fruit Macerate Inhibits Carrageenaninduced Pl cJune 2025 a1005-10190 v173 a

Background: Pleurisy is an inflammatory condition of the pleura that can lead to severe morbidity and mortality. Controlling excessive pleural inflammation is crucial. Xylopia aethiopica, known for its anti-inflammatory properties, may be a potential treatment. Objectives: This study evaluates its immunological mechanisms and toxicological impact. Materials and Methods: Wistar rats were pre-treated with either chloroquine or X. aethiopica fruit macerate before carrageenan-induced pleurisy. Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) levels were measured in blood and pleural exudate via sandwich ELISA. Leukocyte counts were also assessed. Acute and subacute toxicity profiles of the macerate were evaluated in rats. Results: Carrageenan injection induced an inflammatory condition, resulting in increased local and systemic TNF-α and IL-6 levels, with increased leukocyte influx in the pleural cavity. X. aethiopica macerate significantly reduced systemic (p=0.0026) and local (p=0.0004) TNF-α levels, comparable to chloroquine. No acute toxic effects were observed within 48 hours or 14 days. A 28-day oral administration did not induce behavioral changes, and biochemical analyses suggested safety at studied doses. However, histological analyses revealed vascular congestion and inflammation in the liver and kidneys. Conclusion: X. aethiopica macerate exhibits significant anti-inflammatory effects, supporting its potential as a pleurisy treatment. Further research is needed to confirm its clinical applications.

10aanti-inflammatory activity10aPleurisy10aToxicity10aXylopia aethiopica Fruit Macerate1 aKatawa, Gnatoulma1 aBara, Fagdéba, David1 aDaria, Foulounanna1 aTchadie, Pélagie, Edlom1 aGnodja, Tégmaba1 aArndts, Kathrin1 aBatawila, Komlan1 aRitter, Manuel uhttps://www.phcogres.com/article/2025/17/3/105530pres20252238