02520nas a2200253 4500008004100000245012400041210006900165260001400234300001200248490000700260520172700267653002301994653000802017653001002025653001702035653001402052653002502066100001902091700002502110700002102135700001802156700002602174856006602200 2025 eng d00aComparative Efficacy of Different Solvent Extracts of Equisetum diffusum Whole Plant in FCA-induced Arthritic Rat Model0 aComparative Efficacy of Different Solvent Extracts of Equisetum  cJune 2025 a934-9460 v173 a

Background: Equisetum diffusum D. Don (Family Equisetaceae, common name ‘Himalayan horsetail’) is one such medicinally important herb that has a long history of traditional use among different tribal populations of the sub-Himalayan regions in India for treating back discomfort, bone fractures, and dislocations, as well as Rheumatoid Arthritis (RA). Objectives: This study aims to assess the in vivo anti-inflammatory and anti-arthritic characteristics of whole-plant of E. diffusum ethyl acetate (EDEAE) and n-hexane (EDHE) extracts. Materials and Methods: The adjuvant-induced arthritic rat model was utilized for assessing different arthritic parameters. The GC-MS studies was conducted for screening the bioactive phytocomponents in both solvent extracts. Results: In our study, both the EDEAE and EDHE significantly reduced the arthritic scores, normalized body weight, and restored paw-edema and hematological, biochemical, radiological, and histological states. From our GC-MS analysis, we found that EDHE and EDEAE consist of 75 and 133 unique bioactive phytocompounds, respectively. Out of which, eight (8) and seventeen (17) phytocompounds from the EDHE and EDEAE extracts showed the presence of anti-arthritic and/or anti-inflammatory characteristics, respectively. Conclusion: The findings of our study provide solid evidence for the anti-arthritic characteristics of different solvent extracts derived from E. diffusum in a chronic adjuvant-induced arthritic model. However, the EDEAE extract exhibited a more favorable outcome in comparison to the EDHE extract.

10aEquisetum diffusum10aFCA10aGC-MS10aInflammation10aPaw-edema10aRheumatoid Arthritis1 aSarkar, Sourav1 aChakrabarti, Barnana1 aModak, Debabrata1 aDatta, Roopsa1 aBhattacharjee, Soumen uhttps://www.phcogres.com/article/2025/17/3/105530pres20252179