02469nas a2200313   4500008004100000245006100041210006000102260001400162300001200176490000700188520157800195653001501773653001701788653002401805653001601829653003001845653001501875100002101890700001601911700001901927700001901946700002601965700001601991700002402007700002202031700001602053700002002069856006602089       2025                        eng d00aAflatoxin: A Prevalent Toxin in the Demesne of Existence0 aAflatoxin A Prevalent Toxin in the Demesne of Existence  cJune 2025  a740-7540 v173 a<p class="rtejustify">Aflatoxin, a mycotoxin origin from food-borne microbes, poses a significant and remarkable risk to the safety and integrity of food. Mycotoxin-producing fungi can infect goods intended for human and animal consumption, impacting both populations. Among mycotoxins, aflatoxin B<sub>1 </sub>harms many living organisms, including microorganisms, plants, laboratories, pet animals, and cultured cells. Aflatoxins are incredibly liposoluble and easily absorbed from the exposure site, typically entering the bloodstream through the respiratory and gastrointestinal systems. In humans and animals, the reactive form of aflatoxin, AFB<sub>1</sub>, is metabolized through cytochrome P450 microsomal enzymes into aflatoxins-8,9-epoxide, which then binds with DNA and albumins present in blood serum, forming an active-adducts that damage DNA. Aflatoxins are the well-researched class of mycotoxins, with clear correlations to carcinogenic, hepatotoxic, mutagenic, and teratogenic effects. Therefore, aflatoxin detection is crucial for maintaining food safety and public health, as mycotoxins can withstand high temperatures during storage and cooking. Several analytical and chemical methods can detect, identify, and control aflatoxin contamination with precision, contributing to food safety and public health. Further worldwide research is crucial to deepen our understanding of toxic pollutants, toxicity patterns, regulatory mechanisms, and decontamination strategies, as preventing aflatoxin contamination needs adequate funding and collaboration.</p>
10aAflatoxins10aCarcinogenic10aFood-borne microbes10aHepatotoxic10aMutagenic and Teratogenic10aMycotoxins1 aBanerjee, Aishik1 aGhosh, Arup1 aNandi, Amartya1 aSaha, Deyasini1 aSahoo, Santosh, Kumar1 aKundu, Amit1 aNalanda, Revu, Baby1 aPanigrahi, Naresh1 aRoy, Partha1 aMondal, Sumanta  uhttps://www.phcogres.com/article/2025/17/3/105530pres20252183