02098nas a2200217 4500008004100000245013300041210006900174260001700243300001000260490000700270520138800277653002301665653001401688653001901702653001401721653001901735100002201754700002001776700001801796856006601814 2025 eng d00aEthanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat0 aEthanolic Extract of aerial parts of Achyranthes aspera Attenuat cJanuary 2025 a60-690 v173 a

Background: The chemotherapeutic agents used to treat cancer are known to possess potent adverse effects like nephrotoxicity and hepatotoxicity among others. Objectives: The aim of this current study happened to be the isolation of phytoconstituent from Achyranthes aspera and assess the protective effect of the compound against cisplatin-induced hepato- and nephrotoxicity in rats. Materials and Methods: Toluene: Ethyl Acetate (9:1) was used as the solvent system to isolate the phenolic compound from ethanolic extract of the leaves and stem of A. aspera. The isolated compounds were studied using mass spectroscopy, 1H NMR, FT-IR and UV. The effect of the isolated phenolic was assessed by study of various factors like body weight, organ weight, serum biomarkers and histopathological studies. Results: The treatment of cisplatin led to a significant increase the weight of the organs, hepatic and kidney biomarkers in serum suggesting toxicity whereas the the isolated component reversed the elevated levels (p<0.05 compared to positive control). Conclusion: It could be concluded from the results that pretreatment with isolated component (coumarin) was able to attenuate the hepato-and nephron-toxicity induced by anticancer drug cisplatin.

10aAchyranthes aspera10aCisplatin10aHepatotoxicity10aIsolation10aNephrotoxicity1 aChaudhuri, Arijit1 aKataria, Udichi1 aDubey, Anurag uhttps://www.phcogres.com/article/2025/17/1/105530pres20251905