02632nas a2200217 4500008004100000245011700041210006900158260001700227300001000244490000700254520194700261653001802208653002002226653000802246653000802254653001902262100001802281700002502299700002402324856006602348 2025 eng d00aAntimicrobial Potential of Flavonoids (Free and Bound) of Euphorbia hirta against Selected Dermatophytes Strains0 aAntimicrobial Potential of Flavonoids Free and Bound of Euphorbi cJanuary 2025 a42-520 v173 a

Background: Dermatophytosis/Tinea/ringworm is one of the most infectious diseases of humans, caused by invasion of stratum corneum by dermatophytic fungi viz. Trichophyton species, Microsporum species and Epidermophyton species, though not fatal infections are unpleasant, unhygienic to have and re-occurrence is very common. In recent years, especially during and after COVID 19 pandemic, the development of natural products to produce more cost-effective remedies for different diseases that are affordable to the common man is now being explored from plants. Euphorbia hirta of the family Euporbiaceae is well known for its medicinal properties in traditional and folklore medicinal systems. Euphorbia hirta possesses antifungal properties that may be effective against dermatophytic fungi responsible for causing ringworm. Materials and Methods: Different parts of the plant were taken for the extraction of flavonoids by a well-established protocol with some modifications. Agar well diffusion method, Two-fold dilution method and Total activity determination were carried out to establish the antidermatophytic activity of flavonoids from different parts of the plant Results: Significant Inhibition Zone (IZ) and Activity Index (AI) were observed against Microsporum canis, Trichophyton rubrum, and Epidermophyton floccosm from free flavonoid of the leaf; bound flavonoid of fruit; and bound flavonoid of the root. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) recorded were more or less similar to that of standard drugs. Conclusion: The present study suggests metabolite profiling of different parts of E. hirta. Flavonoids from the plant could be used as a source for the development of alternative drugs for the topical treatment of dermatophytosis.

10aDermatophytes10aEuphorbia hirta10aMFC10aMIC10aSkin disorders1 aSharma, Bindu1 aSonger, Vijay, Laxmi1 aMeena, Vinay, Kumar uhttps://www.phcogres.com/article/2025/17/1/105530pres20251694