02353nas a2200193 4500008004100000245008400041210006900125260001600194300001200210490000700222520173600229653001001965653002101975653001501996653002102011100003102032700003402063856006202097 2019 eng d00aAntioxidative Properties of Thymus vulgaris on Liver Rats Induced by Paclitaxel0 aAntioxidative Properties of Thymus vulgaris on Liver Rats Induce cAugust 2019 a315-3200 v113 a

Background: Thymus vulgaris (Thym) is a species of flowering plant in the mint family Lamiaceae with potent antioxidant, and it has been beneficial effects during short‑term administration. Paclitaxel sold under the brand name Tax (Tax) is chemotherapy drug which capable to produce free radicals. Objective: This study was designed to evaluate the effects of Thym against toxic effects of Tax to the liver of rats. Materials and Methods: Sixty‑four male rats were assigned to eight groups: Control normal and Tax control groups (20 mg/kg); Thym groups (4.5, 9, 18 mg/kg), and Tax + Thym‑treated groups (4.5, 9, 18 mg/kg). Treatments were administered intraperitoneally daily for 2 weeks. Griess technique was assessed for determined serum nitrite oxide (NO) level. Aspartate aminotransferase, ALANINE aminotransferase, and alkaline phosphatase concentrations were determined for liver functional disturbances. In addition, liver malondialdehyde (MDA), total antioxidant capacity (TAC), the diameter of hepatocytes, and the central hepatic vein (CHV) were investigated. Results: Tax administration significantly improved liver MDA and NO level, the mean diameter of CHV and hepatocyte, liver enzymes, and decreased TAC level compared to the normal control group (P < 0.001). The Thym and Thym + Tax treatments at all doses significantly reduced the mean diameter of hepatocyte and CHV, liver enzymes, liver MDA, and NO levels and increased TAC level compared to the Tax control group (P < 0.001). Conclusion: It seems that Thym administration improved liver injury induced by Tax in rats.

10aLiver10aOxidative stress10aPaclitaxel10aThymus vulgaris.1 aSalahshoor, Mohammad, Reza1 aRoshankhah, Cyrus, Jalili Shi uhttps://www.phcogres.com/article/2019/11/3/104103prpr4519