02253nas a2200217 4500008004100000245016100041210007100202260001600273300001200289490000700301520149900308653002001807653002401827653001701851653002201868653001401890100002601904700001701930700002601947856006201973 2019 eng d00aIn vitro Studies on the Inhibition of α-Amylase and α-Glucosidase by Hydro-ethanolic Extract of Pluchea lanceolata, Alhagi pseudalhagi, Caesalpinia bonduc0 aIn vitro Studies on the Inhibition of αAmylase and αGlucosidase  cAugust 2019 a310-3140 v113 a

Background: Pluchea lanceolata (Rasna), Alhagi pseudalhagi (Jawasa), and Caesalpinia bonduc (Latakaranja) important medicinal plants widely used in India as folk medicine. These plants have been used to control diabetes in traditional medicinal systems. Objective: In the present study, 50% volume per volume ethanolic extracts of P. lanceolata, A. pseudalhagi, and C. bonduc subjected to in vitro analysis of antidiabetic effect by alpha‑amylase and alpha‑glucosidase inhibitory assay. Materials and Methods: Inhibitory activity of the hydro‑ethanolic extract of the all three plants individually against alpha‑amylase enzyme and alpha‑glucosidase enzyme were examined in different concentrations (3.90–500 µg/mL), where acarbose used as a positive control. Results: The percentage inhibition of P. lanceolata showed the highest alpha‑amylase and alpha‑glucosidase inhibitory activity. Half‑maximal inhibitory concentration value P. lanceolata was found to be 4.83 µg/ml and 11.94 µg/ml for alpha‑amylase and alpha‑glucosidase inhibition. Conclusion: This study suggests that the hydro‑ethanolic extract of all three plants have antidiabetic property, among these three plants P. lanceolata showed potent enzyme inhibition as compared to other plant extracts and standard acarbose.

10aAlpha‑amylase10aAlpha‑glucosidase10aAntidiabetic10aHydro‑ethanolic10ain vitro.1 aSachan, Anupam, Kumar1 aRao, Ch., V.1 aSachan, Nikhil, Kumar uhttps://www.phcogres.com/article/2019/11/3/104103prpr3119