02580nas a2200265 4500008004100000245009500041210006900136260001700205300001200222490000700234520173400241653001501975653001601990653002702006653002102033653002102054100002302075700002902098700001802127700003102145700002502176700002502201700002502226856006302251 2024 eng d00aProtective Activity of Rumex vesicarius Leaf Extract on Doxorubicin Induced Cardiotoxicity0 aProtective Activity of Rumex vesicarius Leaf Extract on Doxorubi cOctober 2024 a748-7560 v163 a

Background: Doxorubicin is an important and efficient anticancer medicine that is widely used to treat several types of cancer. However, its clinical use is limited due to dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress contribute to doxorubicin-induced cardiotoxicity. Objectives: The current study aimed to look into the protective effects of Rumex vesicarius leaves against the doxorubicin induced cardiotoxicity. Materials and Methods: In treatment schedule, thirty male Wistar albino rats were allocated into five groups of six animals each. Cardiotoxicity was induced by single dose administration of Doxorubicin (20 mg/kg b. wt). The standard group received Amlodipine (5 mg/kg b. wt) and treatment groups received Rumex vesicarius leaves extract (200 and 400 mg/kg b. wt). Cardiac serum parameters-LDH, CK-MB, ALT, AST, and calcium and heart tissue LPO, GSH, and CAT levels were estimated. Results: Rats administered with doxorubicin have significantly increased cardiac serum parameters, tissue LPO, and Ca++-ATPase while significantly decreasing tissue GSH, CAT, Na+/K+-ATPase and Mg++-ATPase levels. Pretreatment with extract (400 mg/kg) showed significant protective activity against doxorubicin induced cardiotoxicity. Additionally, histopathological research was significantly reinforced the cardio protective effects of Rumex vesicarius leaves. Conclusion: Rumex vesicarius leaf extract showed significant cardioprotective activity against doxorubicin induced toxicity.

10aAmlodipine10aDoxorubicin10aMembrane bound enzymes10aOxidative stress10aRumex vesicarius1 aRaghavendra, Mitta1 aYadav, Pulala, Raghuveer1 aSushma, Mondi1 aRajesham, Vallala, Venkata1 aAli, Pinjari, Roshan1 aNikitha, Panchareddy1 aRao, Tadikonda, Rama uhttps://www.phcogres.com/article/2024/16/4/105530pres16487