02872nas a2200289 4500008004100000245018000041210006900221260001400290300001200304490000700316520188900323653002602212653001902238653002502257653001902282653001702301653002302318653002202341653003302363100002302396700002102419700001802440700001902458700001702477700002502494856006302519 2024 eng d00aIdentification of Bioactive Ingredients of Traditional Medicinal Plants Psiadia arabica Jaub. Tamarix articulata, Terminalia arjuna and Rhazya stricta by GC-MS in Saudi Arabia0 aIdentification of Bioactive Ingredients of Traditional Medicinal cJune 2024 a570-5730 v163 a

Objectives: This study identified the main bioactive constituents extracted from a mixture containing four plant extracts. Four Saudi Traditional Medicinal plant extracts containing Psiadia arabica Jaub, Tamarix articulata, Terminalia arjuna and Rhazya stricta were identified using GC-Mass. Materials and Methods: The samples Psiadia arabica Jaub, Tamarix articulata, Terminalia arjuna and Rhazya stricta were collected from various regions of Saudi Arabia. The air-dried parts of each plant were powdered and soaked in methanol for 24 hr, except Psiadia arabica Jaub in chloroform. After that, it was obtaining the concentration plant extract through a rotary evaporator. The mixture of plant extracts was analyzed by GC-MS spectrometry. Results: The most abundant compounds identified including heneicosane (7.3%), tetradecane 4,11-dimethyl- (7.11%), Phytol (1.5%), dodecane, 2,6,10-trimethyl- (1.9%) and hexadecane (1.1%), while the lowest concentrations were observed for 10-methylnonadecane, n-hexadecane, tridecane, 2-methyl-, Naphthalene, 1,2,4a,5,6,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)- and Dodecane, 2,6,11-trimethyl-. One of the main constituents noticed in the combination of four plants was heneicosane, which exhibits a strong antimicrobial effect. In addition, phytol showed multiple effects, including anti-inflammatory, antimicrobial, ant nociceptive, anxiolytic, metabolism-modulating and immune-modulating. Conclusion: These functional molecules identified are known to have different biological activities as antioxidant, antimicrobial, anti-proliferative and antidiabetic. Further studies needed to investigate the mechanism of action through signaling pathway in vivo and in vitro study.

10aBioactive ingredients10aGC-MS Analysis10aPsiadia arabica Jaub10aRhazya stricta10aSaudi Arabia10aTamarix articulata10aTerminalia arjuna10aTraditional medicinal plants1 aKumosani, Taha, A.1 aAlnefayee, Abeer1 aBarbour, Elie1 aQari, Mohammed1 aAhmed, Tarek1 aMoselh, Said, Salama uhttps://www.phcogres.com/article/2024/16/3/105530pres16367