02761nas a2200337 4500008004100000245015900041210006900200260001400269300001200283490000700295520165400302653001501956653002901971653001402000653001802014653001802032100002202050700002402072700002702096700002102123700001902144700003002163700002502193700002702218700002402245700002002269700002702289700002302316700002102339856006302360 2024 eng d00aCamel Milk Supplemented with Fenugreek Seeds Improve Lipid Profile, Atherogenic Index and Antioxidative Status in Animal Model of Cardiovascular Disorders0 aCamel Milk Supplemented with Fenugreek Seeds Improve Lipid Profi cJune 2024 a483-4890 v163 a

Background: Despite of advancement in the technology and an improvement in handing of patients with atherosclerosis and Cardiovascular Diseases (CVDs) but the mortality associated with them remains to be highest in all over the globe. The Atherogenic Index of Plasma (AIP) has now been considered to be a best indicator for the analysis of atherosclerosis and CVDs. This study was undertaken to investigate the potential of Fermented camel Milk (FM) and Fenugreek seed powder (FG) on the animal model of CVDs. Materials and Methods: The animal models of atherosclerosis and CVDs were made by feeding of rats with high fat and cholesterol diets and the effect of FM supplemented with FG either alone or in a combination (FGFM) were tested on the lipid profile and AIP by Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), Glutathione Peroxidase (GPx) activity, Total Cholesterol (TC) and small dense Low-Density Lipoprotein (sd-LDL). Results: The data revealed that FM, FG and their combination potentially increased in TAC level (p<0.05) and decreased in lipid peroxidation via reduction in the serum concentrations of MDA. Whereas, experimental rats on FM were fully restored GPx activity. Moreover, FM and FG and their combination lowered TC and sd-LDL concentrations significantly (p<0.05). Conclusion: The novel findings of this study clearly indicated that the FG, FM and FGFM have potential in preventing the onset of atherosclerosis and CVDs by reducing the levels of sd-LDL and improving lipids profile, AIP and antioxidant capacity.

10aCamel milk10aCardiovascular disorders10aFenugreek10aHigh fat diet10aLipid profile1 aAlthwab, Sami, A.1 aAlharby, Thekra, A.1 aAbdulmonem, Waleed, Al1 aMusa, Khalid, H.1 aRasheed, Zafar1 aAljohani, Abdullah, S. M.1 aAlmujaydil, Mona, S.1 aAlghonaim, Bashayr, Y.1 aAlharbi, Nasser, A.1 aRajabi, Ala, Al1 aKhan, Muhammad, Ismail1 aFernández, Nelson1 aHamad, Essam, M. uhttps://www.phcogres.com/article/2024/16/3/105530pres16358