02176nas a2200217   4500008004100000245006700041210006600108260001400174300001200188490000700200520153000207653001301737653002201750653001401772653002301786653002501809653002201834100002101856700001801877856006301895       2024                        eng d00aMechanistic Insights of a Natural Bioactive Compound: Apigenin0 aMechanistic Insights of a Natural Bioactive Compound Apigenin  cJune 2024  a435-4480 v163 a<p class="rtejustify">Apigenin, a natural bioactive compound belonging to the class of flavone, has emerged as a subject of intense scientific scrutiny due to its potential health benefits. This review provides mechanistic insights into the multifaceted actions of apigenin and its promising therapeutic applications. Widely distributed in various fruits, vegetables, and herbs, apigenin exhibits potent antioxidant properties, neutralizing free radicals and reactive oxygen species to combat oxidative stress and cellular damage. Its anti-inflammatory effects are attributed to the inhibition of pro-inflammatory mediators, suggesting potential in managing conditions like arthritis and inflammatory bowel disease. Notably, apigenin's ability to inhibit cancer cell proliferation, induce apoptosis, and reduce metastasis underscores its potential in cancer chemoprevention. Furthermore, apigenin's role in DNA repair and genoprotection may contribute to cancer prevention and maintenance of genomic stability. In neurodegenerative conditions, apigenin's antioxidant and anti-inflammatory actions show promise in protecting neurons and enhancing cognitive function. Additionally, its influence on cardiovascular health is evident through vasodilation, blood pressure reduction, and inhibition of platelet aggregation. While the current findings highlight the immense potential of apigenin in various health applications, further clinical research is necessary to establish its efficacy and safety in human therapeutics.</p>
10aApigenin10aClinical research10aFlavonoid10aHealth application10aMechanistic Insights10aNatural bioactive1 aAdhikari, Tushar1 aSaha, Prerona  uhttps://www.phcogres.com/article/2024/16/3/105530pres16353