02408nas a2200217 4500008004100000024000700041245018300048210006900231260001800300300001200318490000700330520163400337653002101971653002201992653001702014653002202031100001902053700002902072700002602101856006302127 2023 eng d a1900aAnti-atherogenic and Synergistic Effect of Decosapentanoic Acid/Linoleic Acid Fatty Acids via Janus Kinase [JAK] Mediate Inhibition of HMG-CoA Reductase in Rats Fed High Fat Diet0 aAntiatherogenic and Synergistic Effect of Decosapentanoic AcidLi cDecember 2023 a152-1550 v163 a

Introduction: Atherosclerosis is common CHD caused by accumulation of oxidized LDL-c forming foam cell with macrophage that narrowing blood vessels. It increased risk of CVD. Green vegetables rich with PUFA is important to maintain healthy status. This study investigated the mechanistic pathway mediate combination of Decosapentanoic acid (DPA) and linoleic acid (LA) as anti-atherothengic effect in rats fed high fat diet. Materials and Methods: Seventy-five male albino rats were divided into five groups (15 rats each) were fed high fat diet (40% Saturated fat) for 3 months: Group (I): Rats given 10 % DPA. Group (II): Rats given 10 % LA. Group (III): Rats given 10 % DPA+10% LA. Group (IV): Rats treated with atorvastatin (10 mg/kg BW) and Group (v) Untreated. In addition, Group (VI): 15 rats fed normal diet. Results: Data obtained showed that, plasma cholesterol and LDL-c levels were highly significant reduced in group III (p < 0.001) versus other groups compared with untreated. Level of triglycerides was reduced but still high than normal (p=0.05) and atherogenic index. The activity of HMG-CoA reductase was reduced while apo-A, apo-c elevated, JAK was upregulated in combination therapy (p< 0.001). The elevated Apo-A, apo-c activate clearing factor and decreased triglycerides. Conclusion: It was concluded that, upregulated of JAK by combination therapy mediate inhibition of HMG-CoA reductase that decreased endogenous synthesis of cholesterol and reduced its level in circulation.

10aAtherosclerosis.10aHMG-CoA reductase10aJanus kinase10aOmega fatty acids1 aHuwait, Etimad1 aKumosani, Taha, Abdullah1 aMoselhy, Said, Salama uhttps://www.phcogres.com/article/2023/16/1/105530pres16119