02666nas a2200277 4500008004100000024000700041245013400048210006900182260001800251300001200269490000700281520175300288653003102041653001502072653002302087653003002110653003302140100002202173700002002195700002502215700001702240700002302257700001602280700002902296856006302325 2023 eng d a1700aDevelopment and Evaluation of Nephroprotective Polyherbal Formulation against Methotrexate Induced Toxicity in Sprague Dawley Rat0 aDevelopment and Evaluation of Nephroprotective Polyherbal Formul cDecember 2023 a140-1450 v163 a

Methotrexate (MTX) is one of the most broadly used anti-cancer derivative of aminopterin and it is a first folic acid antagonist. Adult cancer, various malignancies, multiple sclerosis, dermatomyositis, sarcoidosis, psoriasis, rheumatoid arthritis, and severe inflammatory disorders are all commonly treated with MTX. Medicinal plants and herbs contribute, wide range of treatment and prevention from several diseases. Herbal formulations mean dosage form consisting of one or more plants prepared herbs in selected quantities to cure mitigate diseases, by treatment, prevention and sometimes use as a supplement. Petrida foetida is used as traditionally diarrhea, stomach ache and nutritional supplement etc. Vitis vinifera, the fruit is used for dietary and the leaves and seeds are used as several herbal therapy. The current study had carried out to evaluate the nephroprotective activity of leaves and seed extracts of Petrida foetida and Vetis venifera. Nephroprotective activities of ethanolic and aqueous extracts of Petrida foetida and Vitis vinifera seeds were examined against methotrexate induced Kidney damage in Sprague Dawley Rats. Biochemical parameter evaluates like Urea, Creatinine, Uric acid, Blood urea nitrogen, total protein like albumin, globulin was analyzed. Petrida foetida and Vitis venifera seeds extract of exhibited significant (p<0.05) nephroprotective activity. Ethanolic seeds extract of Vitis vinifera and Petrida foetida menifest moderate activity upon Methotrexate induced Rat models. Study outcome shows the traditional-ethno medicinal use of Methotrexate as a potential source of Nephroprotective activity.

10aBlood Urea Nitrogen (BUN).10aCreatinine10aMethotrexate (MTX)10aNephroprotective activity10aPolyherbal formulation (PHF)1 aChaudhuri, Arijit1 aKataria, Udichi1 aDubey, Subodh, Kumar1 aChopra, Neha1 aDhanorya, Devendra1 aShah, Kamal1 aChauhan, Nagendra, Singh uhttps://www.phcogres.com/article/2023/16/1/105530pres16117