02701nas a2200301 4500008004100000245015400041210006900195260001700264300001200281490000700293520172800300653002302028653001802051653001602069653002102085653002502106653002502131100001602156700001902172700001902191700001902210700002602229700002802255700002502283700000502308700002202313856006402335 2023 eng d00aPhysicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis0 aPhysicochemical and in vitro Analysis of Herbal Drugs A indica C cOctober 2023 a831-8400 v153 a

Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments.

10aAzadirachta indica10aCurcuma longa10ahaCaT cells10aPongamia pinnata10aPsoralea corylifolia10aWoodfordia fruticosa1 aKumar, Arun1 aSingh, Saurabh1 aKumar, Bimlesh1 aWadhwa, Sheetu1 aBaghel, Dileep, Singh1 aPanday, Narendra, Kumar1 aSingh, Sachin, Kumar1 a1 aPal, Vikas, Kumar uhttps://www.phcogres.com/article/2023/15/4/105530pres154088