01965nas a2200241 4500008004100000024000700041245009600048210006900144260001800213300001200231490000700243520120700250653001601457653000901473653001801482653002301500653001401523100003001537700003701567700002401604700002901628856006601657 2023 eng d a1300aPhysicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice0 aPhysicochemical Toxicity and Antioxidant Activity of Terminalia  cDecember 2022 a119-1270 v153 a

Background: Terminalia catappa Linn. is an ornamental tree belonging to the family Combretaceae. This study was aimed at evaluating the toxicity profile and antioxidant activity of the oil. Materials and Methods: Oral acute and sub-acute toxicity were studied in mice using the Organization for Economic Co-operation and Development (OECD) guidelines. The antioxidant activity was assessed using DPPH free radical. Results: Terminalia catappa seed oil demonstrated antioxidant activity by scavenging DPPH free radical with IC50 of 1.425 mg/mL while tannic acid (standard) was 5.005 mg/mL. The oral LD50 of the oil in mice was greater than 5000 mg/kg. The sub-acute toxicity study, produced no significant difference in the weight and biochemical parameters in treated animals compared to the control. Conclusion: The oil was also non-toxic to the liver, kidney, heart and lungs on histopathological examination. Our results indicated that Terminalia catappa seed oil is not toxic and contains beneficial phytochemical that demonstrated antioxidant activity.

10aAntioxidant10aDPPH10aPhytochemical10aTerminalia catappa10aToxicity.1 aHalilu, Emmanuel, Mshelia1 aUgwah-Oguejiofor, Chinenye, Jane1 aOduncuoğlu, Göksu1 aMatthias, Solomon, Gamde uhttps://www.phcogres.com/article/2023/15/1/105530097484900304