02700nas a2200241 4500008004100000245011000041210007100151260001300222300001200235490000700247520195100254653001402205653002202219653001602241653001702257653001702274653001302291100002102304700002202325700002302347700002602370856006202396 2021 eng d00aEvaluation of Analgesic, Anti‑Inflammatory, and Antipyretic Activity of Piperine: An Experimental Study0 aEvaluation of Analgesic Anti‑Inflammatory and Antipyretic Activi cMay 2020 a176-1800 v123 a

Background: Narcotics (e.g., opioids) or non-narcotics (e.g., salicylates and corticosteroids) are used in the management of pain and inflammation, both of which have side effects, thereby emphasizing the search for natural substances. Piperine found naturally in plants of the Piperaceae family has shown inhibitory activity against 5‑lipoxygenase and cyclooxygenase‑1 in in vitro studies. Objectives: To evaluate the analgesic, anti‑inflammatory, and antipyretic activity of piperine in comparison to aspirin. Materials and Methods: Albino Wistar rats of either sex weighing 180–200 g and Swiss mice weighing 25–30 g were used. The tail‑flick method and hot plate method in rats and acetic acid‑induced writhing method in mice were used for the evaluation of analgesic activity. The carrageenan‑induced paw edema method, cotton pellet‑induced granuloma method, and formalin‑induced arthritis method were used for the evaluation of anti‑inflammatory activity. Baker’s yeast‑induced pyrexia model was used to evaluate antipyretic activity. Results: Piperine showed significant analgesic effect of 40%–55% in tail‑flick method, 58% in hot plate method, and 54% in acetic acid‑induced writhing model, when compared to negative controls. The percentage inhibition of inflammation, in comparison to controls, was significant at 56% for carrageenan‑induced paw edema model and 40% for formalin‑induced arthritis model. In the cotton pellet‑induced granuloma model, however, it was only 10%. In the yeast model of pyrexia, piperine significantly reduced rectal temperature at 4 h. However, aspirin had better effect than piperine in all these models. Conclusion: Piperine exhibits significant analgesic, anti‑inflammatory, and antipyretic activity though not comparable to aspirin.

10aAnalgesic10aAnti-inflammatory10aAntipyretic10aBlack pepper10aPiper nigrum10aPiperine1 aDhargawe, Nikhil1 aMahakalkar, Sunil1 aMohod, Bhagyashree1 aRaj, Jeffrey, Pradeep uhttps://www.phcogres.com/article/2021/12/2/104103prpr9419