02228nas a2200241 4500008004100000024000700041245011800048210006900166260001800235300001000253490000700263520140000270653004401670653005201714653003201766653001401798653001601812653002401828100002201852700002401874700002201898856006601920 2023 eng d a0600aPhysiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches0 aPhysiochemical Characterization and in vitro Evaluation of Formu cDecember 2022 a64-700 v153 a

Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer. Materials and Methods: Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch. Results: The in vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15%, 87.12%, 82.34%, 92.45%, 86.78% and 76.21% at 8hr. The order of drug release was found to be F4>F1>F2>F3>F6>F5. Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactive Vitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

10aDifferential Scanning Calorimetry (DSC)10aFourier-Transform Infrared Spectroscopy (FTIR).10aPhysico-chemical properties10aStability10aTransdermal10aUV/Vis Spectroscopy1 aVerma, Poojashree1 aMaheshwari, Neelesh1 aBairagee, Deepika uhttps://www.phcogres.com/article/2023/15/1/105530097484900244