02297nas a2200241 4500008004100000245008500041210006900126260001400195300001200209490000700221520146500228653003401693653003001727653005101757653002101808653001801829100003801847700002501885700003101910700002101941700003001962856006301992 2022 eng d00aAntihypertensive and Cardioprotective Property of Mimosa pudica Using Zebra Fish0 aAntihypertensive and Cardioprotective Property of Mimosa pudica cJuly 2022 a333-3370 v143 a
Background: Increase in blood pressure is generally termed as hypertension which is one of the common causes of cardiovascular diseases. Despite the several treatment methods, hypertension stands to be the major concern in developing countries. Angiotensin converting enzyme is one of the key contributors in regulating blood pressure where improper activation of angiotensisn leads to hypertension. Mimosa pudica plant has been reported to exhibit several therapeutic properties and thus the current study was focused on evaluating antihypertensive property of phytochemicals found in the Mimosa pudica extract. Materials and Methods: Methanol extract of Mimosa pudica was examined for presence of potential phytochemicals by GC-MS and molecular docking studies were carried out using Autodock 4.2. Results: 07 phytochemicals were identified in the methanol extract of Mimosa pudica. Further molecular docking studies against angiotensin converting enzyme (ACE) was carried out and among the list of test compounds 9,12-octadecadienoic acid showed least binding energy with -6.6 kJ. Conclusion: Compounds selected as phytochemicals of Mimosa pudica from methanol extract of Mimosa pudica, specially 9,12-octadecadienoic acid considered for further evaluation of antihypertensive and cardioprotective activity.
10aAngiotensin converting enzyme10aAntihypertensive activity10aAntihypertensive and cardioprotective activity10aMethanol extract10aMimosa pudica1 aHanumanthappa, Santhosh, Kondajji1 aHarris, Joy, Hoskeri1 aSudhakar, Nivedita, Pujari1 aAshoka, Priyanka1 aHanumanthappa, Manjunatha uhttps://www.phcogres.com/article/2022/14/3/105530pres14349