02094nas a2200253 4500008004100000245012600041210006900167260001400236300001200250490000700262520125000269653003101519653002101550653004101571653002601612653002501638100001401663700001801677700002101695700001801716700002201734700002101756856006301777 2022 eng d00aAnti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats0 aAntiarthritic Potential of Aqueous and Ethanolic Extracts of Eup cJuly 2022 a304-3090 v143 a

Background: Euphorbia helioscopia is of the family Euphorbiaceae, owning various pharmacological properties like anti-inflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic disease that can be characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage. Objectives: To assess the anti-arthritic activity of aqueous and ethanolic extracts of Euphorbia helioscopia. Materials and Methods: Adjuvant-induced arthritis (AIA) method was followed for the evaluation. Complete Freund’s adjuvant (CFA) was used to induce arthritis in female Wistar rats. Aqueous and ethanolic extracts (300, 150, and 75 mg/kg/day) of aerial parts of Euphorbia helioscopia were given orally to Wistar rats. Results: Both the extracts showed significant anti-arthritic activity in a dose-dependent manner. However, ethanolic extract (300mg/kg) of Euphorbia helioscopia showed potential anti-arthritic activity among the tested extracts. Conclusion: From the study, it can be concluded that Euphorbia helioscopia possesses marked anti-arthritic activity.

10aAdjuvant induced arthritis10aAntiinflammatory10aAqueous and ethanolic plant extracts10aEuphorbia helioscopia10aRheumatoid Arthritis1 aJan, Iram1 aDogra, Ashish1 aHaq, Syed, Assim1 aDhiman, Sumit1 aSingh, Gurdarshan1 aKumar, Mithilesh uhttps://www.phcogres.com/article/2022/14/3/105530pres14344