02423nas a2200289 4500008004100000245008500041210007100126260001600197300001200213490000700225520148400232653001901716653001701735653003301752653001701785653005201802100003301854700002701887700001801914700002601932700002201958700002201980700002002002700003102022700001702053856006302070 2019 eng d00aIn silico Anti‑Preeclampsia Potential of Phytochemical Found in Ficus elastica0 aIn silico Anti‑Preeclampsia Potential of Phytochemical Found in  cAugust 2019 a279-2820 v113 a

Context: Preeclampsia (PE) is a disorder found in pregnant women characterized by high blood pressure and high protein content in urine. Delivery of the baby and placenta is the most recommended treatment in PE, but treating its symptoms (hypertension) has also been recommended. Aims: This study is intended to assess the major compounds found in Ficus elastica leaf as anti‑PE using an in silico approach. Settings and Design: All in silico analysis was performed under default settings. Subjects and Methods: Antioxidant and anti‑inflammatory probability values of the five compounds in F. elastica leaf are predicted using quantitative structure–activity relationship. The possible binding mode of the compounds is predicted using molecular docking. Results: Based on the structural properties, compounds found in F. elastica leaf have a high probability activity as an antioxidant and anti‑inflammatory. The compounds found in F. elastica, especially morin, have the highest binding affinity toward beta‑adrenergic receptor 2 (ADRB2) with similar intermolecular interaction with its known inhibitor. Conclusions: The compounds found in F. elastica may be beneficial for treating PE through its possible antioxidant and anti‑inflammatory properties and inhibition of ADRB2. Key words: Ficus elastica, hypertension, molecular docking.

10aFicus elastica10aHypertension10aMolecular docking simulation10aPreeclampsia10aQuantitative structure–activity relationship.1 aGinting, Chrismis, Novalinda1 aLister, Nyoman, Ehrich1 aGirsang, Ermi1 aPutri, Yolanda, Eliza1 aMutia, Maya, Sari1 aPurba, Riastawaty1 aWidowati, Wahyu1 aWibowo, Satrio, Haryo Beno1 aRizal, Rizal uhttps://www.phcogres.com/article/2019/11/3/104103prpr17618