02739nas a2200241 4500008004100000245010000041210006900141260001800210300001000228490000700238520196500245653001602210653001802226653002402244653003002268653002002298100003502318700002402353700001902377700001602396700002402412856006102436 2022 eng d00aAntidiarrheal and Antioxidant Activities of the Aerial Parts of Caralluma dalzielii N. E. Brown0 aAntidiarrheal and Antioxidant Activities of the Aerial Parts of  cDecember 2021 a82-880 v143 a

Background: Caralluma dalzielii N.E. Brown is commonly referred to as “Karan massalanci” in the Northwest Nigeria where it is used in treating several ailments including pain, diarrhea and stomach issues. Objectives: This study was aimed to investigate the antidiarrheal and antioxidant activities of aqueous aerial parts extract of Caralluma dalzielii. Materials and Methods: The aqueous aerial parts extract of Caralluma dalzielii (CDE) (100, 200 and 400 mg/kg) was evaluated for antidiarrheal properties against gastrointestinal motility, castor oil-induced and prostaglandin-E2 (PGE2) enteropooling models in Wistar rats. Its antioxidant properties were studied by determining the total phenolic content (TPC) using Folin-Ciocalteu reagent, its free radical scavenging activity using 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) and its ferric reducing antioxidant power (FRAP) assays using potassium ferrocyanide ferric chloride methods. Ascorbic acid was used as the reference. Spasmolytic effect was studied in isolated rabbit jejunum preparations in an organ bath experiment using acetylcholine (ACh). Results: CDE significantly (p<0.05) reduced gastrointestinal transit of charcoal meal and the total number of diarrheal feces in the animals. The total phenolic content was determined to be 36.67±3.33 mg GAE/g. IC50 value of 63.44 mg/mL was calculated in DPPH assay. The FRAP value was found to increase as the concentration of the extract increased. CDE inhibited acetylcholine-induced contraction of the rabbit jejunum in a concentration dependent manner with complete inhibition at 20.48 mg/mL of the extract. Conclusion: The extract of Caralluma dalzielii possesses antidiarrheal activities which may be related to its antimotility, antioxidant and antispasmodic properties.

10aAntioxidant10aAntispasmodic10aCaralluma dalzielii10aGastrointestinal motility10aRabbit jejunum.1 aUgwah-Oguejiofor, Chinenye, J.1 aMshelia, Halilu, E.1 aBello, Junaidu1 aInuwa, Isah1 aSulaiman, Abdullahi uhttps://phcogres.com/fulltext/v14i1/105530pres14112.html