02102nas a2200253 4500008004100000245014300041210006900184260001800253300000800271490000700279520128600286653001701572653001201589653001501601653002201616653002001638653001701658100002301675700001801698700001901716700002901735700002401764856006001788 2022 eng d00aPreventive Effects of Ginger Extract and Nigella sativa Oil on Anxiety and Depression Behavior in Wistar Rats Exposed to Mercuric Chloride0 aPreventive Effects of Ginger Extract and Nigella sativa Oil on A cDecember 2021 a1-40 v143 a

Background: Mercuric chloride (HgCl2) is toxic to humans and animals, and usually causes systemic and nerve damage. Aim: The aim of this study is to evaluate the neuro-protective effects of two medicinal plants rich in antioxidants against mercuric chloride poisoning in Wistar rats. Materials and Methods: This is an experimental study conducted on twenty-five adult rats randomly divided into five groups of five rats each, the untreated control group and the four groups are treated daily with Ginger extract (500 mg/kg/day) and Nigella sativa oil (2ml/kg/day) for four weeks. The administration of mercuric chloride (4mg/kg/day) will be from the second week of experimentation to three weeks. Results: The results obtained showed by behavioral tests that the administration of inorganic mercury (HgCl2) significantly increases the state of anxiety and depression of rats compared to control rats, while the groups pre-treated with antioxidants can reduce the damage of these behavioral disorders. Conclusion: Ginger extract and Nigella sativa oil have a very important role in neurobehavioral alterations induced by mercury toxicity.

10aAntioxidants10aAnxiety10aDepression10aMercuric Chloride10aNeuroprotection10aWistar Rats.1 aBenkermiche, Sabri1 aDjemli, Samir1 aHaloui, Meriem1 aBenabed, Mohamed, Lamine1 aTahraoui, Abdelkrim uhttps://phcogres.com/fulltext/v14i1/105530pres1411.html