02985nas a2200349 4500008004100000245010500041210006900146260001800215300001000233490000700243520190800250653001402158653002202172653001702194653002402211653001002235100001502245700003002260700002802290700002302318700001802341700002302359700002702382700002002409700002302429700002602452700002802478700002402506700002602530700001902556856006002575 2022 eng d00aAnalgesic, Anti-inflammatory, and Anti-pyretic Activities of Crinum pedunculatum R.Br. Bulb Extracts0 aAnalgesic Antiinflammatory and Antipyretic Activities of Crinum  cDecember 2021 a24-290 v143 a

Background: Crinum pedunculatum R.Br. bulbs are used for the topical management of inflammation by traditional healers in the southern region of Ghana. Objectives: This study aims to assess the analgesic, anti-inflammatory, and anti-pyretic activities of different solvent extracts of Crinum pedunculatum. Methods: The analgesic, anti-inflammatory, and anti-pyretic activities of the bulb extracts of Crinum pedunculatum were determined in rats at doses of 100, 200, and 400 mg/kg. The acetic acid induced writhing test was used to determine the analgesic activity, carrageenan was employed to determine the anti-inflammatory activity, and Brewer’s yeast-induced pyrexia was studied to evaluate the extract’s anti-pyretic activity. Results: All solvent extracts of Crinum pedunculatum significantly decreased (P < 0.001) the frequency of writhing in rats at all doses with 400 mg/kg of the ethanolic extract showing a 98% inhibition comparable to that obtained with diclofenac sodium at 94%. These extracts also caused the inhibition of the increase in paw diameter induced by the administration of carrageenan with 400 mg/kg of the ethyl acetate extract of Crinum pedunculatum causing a 97% inhibition of paw oedema. All doses (100, 200, and 400 mg/kg) of the methanol extract caused a significant decrease (P < 0.0001) in the temperature of rats induced via the administration of yeast with ethanol and ethyl acetate extracts also showed a significant reduction (P < 0.001) in rectal temperature. Conclusion: These results obtained indicate that the methanolic, ethanolic, and ethyl acetate extracts of Crinum pedunculatum R.Br. possess analgesic, anti-inflammatory, and antipyretic activities.

10aAnalgesic10aAnti-inflammatory10aAnti-pyretic10aCrinum pedunculatum10aRats.1 aDoe, Peace1 aDanquah, Cynthia, Amaning1 aOhemeng, Kwasi, Adomako1 aOpare, Ako, Ernest1 aSharif, Ahmed1 aAkua-Abora, Dorcas1 aAkuoko, Asamoah, Kwame1 aKpabitey, Aaron1 aQuarshie, Emmanuel1 aAsante, Oliver, Opoku1 aAmponsah, Elvis, Kwadwo1 aMutwaliku, Mariyana1 aNuro-Brefo, Charlotte1 aOfori, Micheal uhttps://phcogres.com/fulltext/v14i1/105530pres1415.html