02790nas a2200289 4500008004100000245008800041210006900129260001700198300001200215490000700227520189400234653001602128653001602144653001302160653002102173653002202194653001502216100002502231700003302256700002002289700003302309700003002342700002002372700002902392700001602421856006302437 2021 eng d00aPreventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-190 aPreventive Medicinal Plants and their Phytoconstituents against  cOctober 2021 a173-1910 v133 a

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale are now targeting approaches globally as a preventive care against SARS-CoV-2. Aim: This review is primarily focused on to deliver a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Experimental procedure: In this study, science mapping tool Bibliometrix R-package was used to perform bibliometric analysis and building data matrices for keywords co-occurrence investigation, country-wise scientific production; collaboration between the countries worldwide, co-word analysis on topic “keywords associated with SARS-CoV-2 and medicinal plants”. Results and Conclusion: Our findings is to deliver a concise knowledge about the coronaviridae family, pathophysiology, possible targets for managing the SARS-CoV-2, in addition to potential medicinal plants and their phytoconstituents against COVID-19. Target-specific inflammatory pathways due to post infection of SARS e.g. NLRP3, p38-MAPK, Metallopeptidase Domain 17; endocytosis pathways e.g. Clathrin, HMGB1 pathways are primarily highlighted along with relevant interleukins and cytokines, which directly/indirectly triggering to immune system and play a significant role. Based on selective pathways and potential lead, the outcome of our elaborated study put forward selected Indian medicinal plants that hold a very high probability as preventive care in this global crisis.

10aBiblioshiny10aCoronavirus10aCOVID-1910aMedicinal plants10aPhytoconstituents10aSARS-CoV-21 aNema, Neelesh, Kumar1 aMamdapur, Ghouse, Modin Nabe1 aSarojam, Smitha1 aKhamborkar, Swapnil, Devidas1 aSajan, Linson, Cheruveett1 aSabu, Sachithra1 aChacko, Baby, Kumarantha1 aJacob, Viju uhttps://www.phcogres.com/article/2021/13/4/105530pres13410