@article {1129, title = {Abrogation of Acute Inflammation in ICR Mice with Topical Administration of Philippine Stingless Bee (Tetragonula biroi Friese) Honey}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {February 2023}, pages = {258-266}, type = {Original Article }, chapter = {258}, abstract = {

Background: Honey, a sweet sugar-rich bee-derived product, has been widely recognized in the realm of Ayurveda and Pharmacognosy for the treatment of various inflammatory conditions including inflammatory bowel disease, asthma, arthritis, and gastric ulcer. However, the anti-inflammatory effect of Philippine honey obtained from local stingless bees remains unexplored and poorly investigated. Hence, this study delved on the anti-inflammatory potential of topically applied Philippine stingless bee honey (PSH) using the λ-Carrageenan-induced mouse model of paw edema. Materials and Methods: A total of 30, male ICR mice of six weeks of age were randomly divided into the following groups (n=10 per group) as follows: Distilled water-, 1\% Diclofenac sodium-, and Honey-treated group. All treatments were administered immediately after Carrageenan injection and then every 8 hr during the 24-hr test duration. Results: Repeated topical application of PSH significantly attenuated the gross hind paw swelling observed at the onset of the 6 hr post-induction (pi) until the 24 hr pi with Carrageenan in contrast to the Distilled water-treated group. This corresponded histologically to a marked reduction in dermal thickness, dermal edema, and leukocytic infiltration. Whereas, at the cytokine level, this correlated to significant suppression of the circulating blood levels of pro-inflammatory cytokines, TNF-α, IL-1β, and IL-6. Conclusion: Based on these results, honey from the Philippine stingless bees shows convincing anti-inflammatory activity which is partly mediated through the regulation of the expression of inflammation-associated cytokines.

}, keywords = {Anti-inflammatory, Honey, IL-1β, IL-6, Philippine stingless bees, TNF-α.}, doi = {10.5530/pres.15.2.028}, author = {Mark Joseph Maranan Desamero and Mikaela Bernadette Andres Rabino and Maria Angelica Rimas Tayao and Mary Jasmin Cabillon Ang and Jussiaea Valente Bariuan and Roxanne Posilero Gapasin and Therese Marie Avena Collantes and Melissa Marie Risos Rondina and Cherry Pambid Fernandez-Colorado and Cleofas Rodriguez Cervancia and Maria Amelita Celino Estacio} } @article {1085, title = {Chemistry and Pharmacology of Honey}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {356-359}, type = {Review Article}, chapter = {356}, abstract = {

Honey which is obtained from Apis mellifera has wide uses due to its chemical constituents present in it. World Wide honey is used for nutritious and medicinal purposes. The review would give the platform to the readers, researchers, scholars to have clear view of the chemical components, its probable mechanism, pharmacological activity and comparison of its ancient uses. Apart from pharmacological, nutritional and non-nutritional components its side effects are also discussed. This review would be an insight for the researchers in the field of medicine.

}, keywords = {Adverse effects, anti-oxidant, Honey, Non-nutritional, Nutritional, Pharmacological}, doi = {10.5530/pres.14.4.53}, author = {Kamal Shah and Sumit Chhabra and Nagendra Singh Chauhan} } @article {239, title = {Characterization of the Gain and Loss of Resistance to Antibiotics versus Tolerance to Honey as an Antimutagenic and Antimicrobial Medium in Extended-Time Serial Transfer Experiments}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {April 2019}, pages = {147-154}, type = {Original Article}, chapter = {147}, abstract = {

Background: Honey contains several substances with antimicrobial properties that appear more recalcitrant to generating bacterial-evolved resistance than traditional antibiotics. Objectives: This study seeks to characterize the evolution of bacteria grown for successive generations in honey as an antimutagenic medium versus ampicillin. Materials and Methods: A naive strain of Staphylococcus aureus was serially cultured for 17 days in Lysogeny broth (LB) containing sublethal concentrations of medical-grade Manuka honey, polyfloral honey, and ampicillin. Glucose as an osmotic control and pure LB were included for comparison. A portion of each culture was removed every 24 h to (a) determine the amount of growth that occurred during the previous 24 h and (b) use as a genetic stock in serially transferred tubes containing the same inhibitory compound as used previously. Results: As indicated by an increase in growth over sequential 24-h period, bacteria rapidly gained resistance to ampicillin in a step-wise pattern. However, bacteria grown in Manuka and polyfloral honey never exceeded their initial growth levels. Bacteria grown in relatively high concentrations of honey for a single 24-h period consistently lost viability after one transfer, a phenomenon that has not been reported in the literature before and which indicates the inability of bacteria to adapt to honey as an antimutagenic medium. While bacteria grown in honey did not evolve the ability to grow at higher concentrations, a single isolate grown in Manuka honey gained tolerance to Manuka by successfully surviving and proliferating beyond second transfers. Bacteria that developed antibiotic resistance were found to remain sensitive to honey. Moreover, bacteria lost their resistance to ampicillin upon a single exposure to Manuka honey.

}, keywords = {Antibiotic resistance, Antimutagenicity, Honey, Manuka, Polyfloral, Second transfer crash}, doi = {10.4103/pr.pr_175_18}, author = {Salma G. Abdel-Azim and Ahmad G. Abdel-Azim and Brian P. Piasecki and Gamal A. Abdel-Azim} } @article {316, title = {Honey and Health: A Review of Recent Clinical Research}, journal = {Pharmacognosy Research}, volume = {9}, year = {2017}, month = {April 2017}, pages = {121-127}, type = {Review Article}, chapter = {121}, abstract = {

Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment. The aim of this review is to emphasize the ability of honey and its multitude in medicinal aspects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement. The ingredients of honey have been reported to exert antioxidant, antimicrobial, anti-inflammatory, antiproliferative, anticancer, and antimetastatic effects. Many evidences suggest the use of honey in the control and treatment of wounds, diabetes mellitus, cancer, asthma, and also cardiovascular, neurological, and gastrointestinal diseases. Honey has a potential therapeutic role in the treatment of disease by phytochemical, anti-inflammatory, antimicrobial, and antioxidant properties. Flavonoids and polyphenols, which act as antioxidants, are two main bioactive molecules present in honey. According to modern scientific literature, honey may be useful and has protective effects for the treatment of various disease conditions such as diabetes mellitus, respiratory, gastrointestinal, cardiovascular, and nervous systems, even it is useful in cancer treatment because many types of antioxidant are present in honey. In conclusion, honey could be considered as a natural therapeutic agent for various medicinal purposes. Sufficient evidence exists recommending the use of honey in the management of disease conditions. Based on these facts, the use of honey in clinical wards is highly recommended.

}, keywords = {Antioxidant, Flavonoids, Honey, Polyphenols, Therapeutic agent, Traditional}, doi = {10.4103/0974-8490.204647}, author = {Saeed Samarghandian and Tahereh Farkhondeh and Fariborz Samini} }