@article {233, title = {Anti-inflammatory Effect of an Extract of Agave americana on Experimental Animals}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {February 2018}, pages = {104-108}, type = {Original Article}, chapter = {104}, abstract = {

Background: Medicinal plants have the potential treasure to treat medical conditions for a long time based on error and trial method. Agave americana has been known as century plant or American aloe. The leaves contain genins, saponins, steroidal flavonoids, isoflavones, and coumarins. It has long been used for anti-inflammatory effects. Objectives: This study was designed to evaluate the anti-inflammatory activity of the extract of A. americana. Materials and Methods: A. americana leaves extract is collected and the extract is done by percolation method. Inflammation is induced in experimental animals{\textquoteright} carrageenan-induced paw edema model and cotton pellet-induced granuloma model. The extract of A. americana and standard, aspirin and indomethacin are given orally for the anti-inflammatory effects. The anti-inflammatory effects were measured at regular intervals of time to see the percentage inhibition of paw edema and reduction of weight of granuloma with percentage protection to compare the effect of the extract with the control and standard. Results: The extract of A. americana showed improved in percentage inhibition of paw edema in graded doses of hydroalcoholic extract of A. americana (HEAA) as compared with control in carrageenan-induced paw edema model. The percentage inhibition of 400 mg/kg of HEAA at the 3rd h is almost comparable with the standard, aspirin. On the other hand, graded doses (200 and 400 mg/kg) showed a highly significant reduction (P \< 0.001) in the weights of granuloma in comparison with the control in cotton pellet-induced granuloma model. The percentage inhibition of weight of granuloma by 400 mg/kg of HEAA is quite comparable to the standard, Indomethacin. Conclusion: Anti-inflammatory activity is seen with the graded dose of HEAA. The plant contains flavonoids and genins which have been shown to have anti-edematous effects in the acute phase of inflammation. Thus, the plant contributes to its anti-inflammatory activity. Thus, higher doses of A. americana leaves need to be used to have the better understanding of the mechanism of anti-inflammation.

}, keywords = {Agave americana, Anti-inflammatory, Aspirin, Flavonoids, Genins, Indomethacin}, doi = {10.4103/pr.pr_64_17}, author = {Arup Kumar Misra and Sushil Kumar Varma and Ranjeet Kumar} } @article {925, title = {Antiulcer Activity of Methanol Extract of Erythrina indica Lam. Leaves in Experimental Animals}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {396-401}, type = {Original Article}, chapter = {396}, abstract = {

Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5{\textendash}10\% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of methanol extract of Erythrina indica (family: Febaceae) leaves in pylorus ligated and indomethacin induced ulceration in the albino rats. Preliminary methanol extract of E. indica was subjected to the acute oral toxicity study according to the OECD guideline no. 423. Based on which, three dose levels i.e. 125, 250 and 500mg/kg were selected for the further study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for indomethacin induced ulcer model. Ranitidine at 100mg/kg was used as the standard drug. Pretreatment of methanol extract of E. indica leaves showed significant (P\<0.01) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly (P\<0.05) increased only at higher dose, 500mg/kg. It showed also significant (P\<0.01) decrease in number of ulcers and ulcer score index in pylorus ligation and indomethacin induced ulceration models. The methanol extract of E. indica leaves possess significant antiulcer properties in a dose dependent manner. In conclusion the antiulcer properties of the extract may be attributed to the polyphenolic compounds that are present in it.

}, keywords = {Antiulcer activity, E. indica, Indomethacin, ranitidine}, doi = {Nil}, author = {S Sakat Sachin and Juvekar Archana} }