@article {1370, title = {Effect of a Thermogenic Composition on Healthy Adult Women and Men in a 12-Week Weight Management Study}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {100-107}, type = {Original Article}, chapter = {100}, abstract = {

Background: Weight loss medications can have severe side effects and thus there is a need to identify safe and effective alternative treatments. Dietinduced thermogenesis and a potential stimulation of fat metabolism might be achieved by consumption of certain foods. Objectives: The aim of the present study was to explore the effects of a Thermogenic Composition (TC) composed of dihydrocapsiate, red pepper (Capsicum annuum), citrus (Citrus spp.) peel extract, Coleus forskohlii and African mango (Irvingia gabonensis) to support body composition, weight management and improve satiety in healthy adults. Methods: Thirty-six participants were instructed to take TC daily over a 12-week interval. Body composition, energy levels, feelings of hunger and satiety were measured. Results: Body Fat percentage showed significant reduction at week 7 and 12 compared to week 0. Waist to Hip Ratio results showed significant reduction at week 7 compared to week 0. Feelings of Hunger and Feelings of Fullness showed significant improvement at week 3, 7 and 12 compared to week 0. Desire to Eat showed a significant reduction at week 3,7 and 12 compared to week 0. Appetite showed significant reduction at week 7 and 12 compared to week 0. Conclusion: TC showed significant improvements in hunger cravings and feelings of fullness as well as significant reduction in percent body fat and waist to hip ratio. The good safety and tolerability profile of TC supported its use as a daily nutritional supplement for weight management and body composition.

}, keywords = {African mango (Irvingia gabonensis), Citrus (Citrus spp) peel extract, Coleus forskohlii, dihydrocapsiate, Red pepper (Capsicum annuum), Thermogenesis}, doi = {10.5530/pres.20251936}, author = {Millerlandy Popayan Jaramillo and David Vollmer and Xuesheng Han} } @article {222, title = {Thermogenic Blend Alone or in Combination with Whey Protein Supplement Stimulates Fat Metabolism and Improves Body Composition in Mice}, journal = {Pharmacognosy Research}, volume = {10}, year = {2018}, month = {February 2018}, pages = {37-43}, type = {Original Article}, chapter = {37}, abstract = {

Background: Certain food ingredients promote thermogenesis and fat loss. Similarly, whey protein improves body composition. Due to this potential synergistic effect, a blend of thermogenic food ingredients containing African mango, citrus fruit extract, Coleus forskohlii, dihydrocapsiate, and red pepper was tested alone and in combination with a whey protein supplement for its effects on body composition in sedentary mice during high-fat diet. Objective: The objective of this study was to evaluate the interaction of thermogenic foods on improving body composition during consumption of an unhealthy diet. Materials and Methods: C57BL/6J young adult male mice (n = 12) were placed on a 60\% high-fat diet for 4 weeks and subsequently randomly assigned to receive daily dosing by oral gavage of vehicle, the novel blend alone or with whey protein supplement for another 4 weeks. Body composition, thermal imaging of brown adipose tissue (BAT), mitochondrial BAT uncoupling protein 1 (UCP1), and plasma levels of leptin were assessed. Results: Novel blend alone and in combination with protein supplement attenuated body weight gain, fat, and increased surface BAT temperature in comparison to vehicle control and to baseline (P \< 0.5). The combination of novel blend and whey protein supplement also significantly increased UCP1 protein expression in BAT mitochondria in comparison to vehicle control and novel blend alone (P \< 0.5). Conclusions: These data indicate that this novel blend stimulates thermogenesis and attenuates the gain in body weight and fat in response to high-fat diet in mice and these effects were improved when administered in combination with whey protein supplement.

}, keywords = {African mango, Capsiate, Forskolin, Synephrine, Thermogenesis, Whey protein}, doi = {10.4103/pr.pr_53_17}, author = {Paula de Lima Vieira-Brock and Brent M. Vaughan and David L. Vollmer} }