@article {169, title = {Effect of Carbon Tetrachloride-induced Hepatic Injury on Luffa acutangula (var.) Amara}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {August 2020}, pages = {278-284}, type = {Original Article}, chapter = {278}, abstract = {

Objectives: To study the reversal effect of carbon tetrachloride (CCl4)-induced hepatic injury on the ethyl acetate and ethanol extracts of Luffa acutangula var. amara in Wistar rats. Materials and Methods: The study included experimental mice groups in which pentobarbital-induced sleeping time and its prolongation by CCl4 is assessed by righting reflex and recovery time. Chronic liver injury was induced by oral administration of CCl4 and acute injury by a single intraperitoneal injection in experimental Wistar rats. Blood and liver specimens were used for analysis of enzymatic reactions. Results: It was noted that the mice groups treated with extracts decrease the sleeping time in and standard silymarin than the control group. Acute and chronic liver injury models showed increases in total protein and glutathione peroxidase, whereas there was a reduction in total bilirubin and serum alkaline phosphate level in extracts and standard silymarin-treated rats than control. Histopathological studies showed a significant reduction in inflammation, fatty change and gross necrosis in extracts and standard silymarin-treated animals than control. Conclusion: The study suggests that extracts of L. acutangula var. amara can be useful in treating acute and chronic hepatic injury.

}, keywords = {Aspartate aminotransferase, Carbon tetrachloride, Hepatoprotective, Luffa acutangula, Silymarin, Wistar rats}, doi = {10.4103/pr.pr_113_19}, author = {E Prabhu Daniel and AR Vijayakumar and W Clement Atlee and R Ilavarasan and M Sivakumar} } @article {190, title = {Phytochemical and Pharmacological Screening of Begonia grandis Dryand}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {January 2021}, pages = {375-379}, type = {Original Article}, chapter = {375}, abstract = {

Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl4-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

}, keywords = {Antioxidant, Begonia grandis, Begoniaceae, Ethnomedicinal, Hepatoprotective, Silymarin}, doi = {10.4103/pr.pr_67_20}, author = {Srinivasarao Pendy and Krishna Nallamothu and Ganapaty Seru and Sunitha Katta and Sumanta Mondal} } @article {719, title = {Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {April 2011}, pages = {13-18}, type = {Original Article}, chapter = {13}, abstract = {

Background:\ There is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat drug-induced liver damage. Leaves of Sacred/Holy Basil, i.e. Green Tulsi (Ocimum sanctum), belonging to family Lamiaceae are used traditionally for their hepatoprotective effect. We wanted to evaluate the hepatoprotective activity of\ Ocimum sanctum and observe whether synergistic hepatoprotection exists with silymarin.\ Materials andMethods:\ Albino rats (150-200 g) were divided into five groups. Groups A and B were normal and experimental controls, respectively. Groups C, D and E received the alcoholic extract of\ Ocimum Sanctum\ leaves (OSE) 200 mg/kg BW/day, silymarin 100 mg/kg BW/day and OSE 100 mg/kg BW/day + silymarin 50 mg/kg BW/day p.o., respectively, for 10 days. Hepatotoxicity was induced in Groups B, C, D and E on the eighth day with paracetamol 2 g/kg BW/day. The hepatoprotective effect was evaluated by performing an assay of the serum proteins, albumin globulin ratio, alkaline phosphatase, transaminases and liver histopathology. The assay results were presented as mean and standard error of mean (SEM) for each group. The study group was compared with the control group by one-way ANOVA, followed by Bonferoni{\textquoteright}s test. A\ P-value of \<0.01 was considered significant.\ Results:\ In groups C, D and E, liver enzymes and albumin globulin ratio were significantly (P\ \< 0.01) closer to normal than in group B. Reduction in sinusoidal congestion, cloudy swelling and fatty changes and regenerative areas of the liver were observed on histopathological examination in groups C, D and E, whereas group B showed only hepatic necrosis.\ Conclusion:\ The Ocimum sanctum alcoholic leaf extract shows significant hepatoprotective activity and synergism with silymarin.

}, keywords = {Hepatoprotective, Hepatotoxicity, Ocimum sanctum, Paracetamol, Silymarin}, doi = {10.4103/0974-8490.79110}, author = {Kingshuk Lahon and Swarnamoni Das} }