@article {1190, title = {Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {813-818}, type = {Original Article}, chapter = {813}, abstract = {

Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p\<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p\<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p\<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future.

}, keywords = {Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensis}, doi = {10.5530/pres.15.4.086}, author = {Thopireddy Lavanya and Kakarla Chandra Mohan and Kesireddy Sathyavelu Reddy and Saddala Rajeswara Reddy} } @article {308, title = {Ashwagandha Reverses the Dieldrin-induced Cognitive Impairment by Modulation of Oxidative Stress in Rat Brain}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {February,2019}, pages = {92-97}, type = {Short Communication}, chapter = {92}, abstract = {

Dieldrin (DLD) is an organochlorine pesticide heavily used in agriculture to control pests. Widespread exposures of DLD to human population are likely to contribute in neurological disorders. Withania somnifera (WSF), commonly known as {\textquotedblleft}ashwagandha,{\textquotedblright} is used for its broad spectrum of pharmacological activity. The present study was designed to investigate the effect of WSF (100 mg/kg) on DLD (5 mg/kg)-induced modulation of cognitive function and oxidative stress in male Wistar rats. Cognitive function was measured using step-down latency (SDL) on a continuous avoidance apparatus and transfer latency (TL) on an elevated plus maze. Oxidative stress was estimated by measuring brain malondialdehyde (MDA) level, protein carbonyl (PC), and reduced glutathione (GSH) activity. Significant reduction in both acquisition and retention in SDL was found for the DLD-treated group at the end of the exposure study as compared to the control (P \< 0.001). DLD caused a significant prolongation in both acquisition and retention in TL after 28 days of the treatment as compared to the control (P \< 0.001). Four-week treatment of WSF antagonized the effect of DLD on SDL and TL at the 29th day. DLD produced a statistically significant increase in the brain MDA and PC levels (P \< 0.001), and a significant decrease in the brain GSH activity (P \< 0.001). Treatment with WSF attenuated the effect of DLD on MDA, PC, and GSH activities. Thus, the finding of this study suggests that WSF has potential in reversing cognitive dysfunction and oxidative stress induced by toxicants such as DLD in the brain.

}, keywords = {Ashwagandha, Dieldrin, Glutathione, Malondialdehyde, Protein carbonyl.}, doi = {10.4103/pr.pr_77_18}, author = {Tandra Ghosh and Sanvidhan G. Suke and Chandrashekhar Yadav and Rafat Ahmed and Basu Deb Banerjee} } @article {148, title = {Ashwagandha Reverses the Dieldrin-induced Cognitive Impairment by Modulation of Oxidative Stress in Rat Brain}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {February 2019}, pages = {92-97}, type = {Short Communication}, chapter = {92}, abstract = {

Dieldrin (DLD) is an organochlorine pesticide heavily used in agriculture to control pests. Widespread exposures of DLD to human population are likely to contribute in neurological disorders. Withania somnifera (WSF), commonly known as {\textquotedblleft}ashwagandha,{\textquotedblright} is used for its broad spectrum of pharmacological activity. The present study was designed to investigate the effect of WSF (100 mg/kg) on DLD (5 mg/kg)-induced modulation of cognitive function and oxidative stress in male Wistar rats. Cognitive function was measured using step-down latency (SDL) on a continuous avoidance apparatus and transfer latency (TL) on an elevated plus maze. Oxidative stress was estimated by measuring brain malondialdehyde (MDA) level, protein carbonyl (PC), and reduced glutathione (GSH) activity. Significant reduction in both acquisition and retention in SDL was found for the DLD-treated group at the end of the exposure study as compared to the control (P \< 0.001). DLD caused a significant prolongation in both acquisition and retention in TL after 28 days of the treatment as compared to the control (P \< 0.001). Four-week treatment of WSF antagonized the effect of DLD on SDL and TL at the 29th day. DLD produced a statistically significant increase in the brain MDA and PC levels (P \< 0.001), and a significant decrease in the brain GSH activity (P \< 0.001). Treatment with WSF attenuated the effect of DLD on MDA, PC, and GSH activities. Thus, the finding of this study suggests that WSF has potential in reversing cognitive dysfunction and oxidative stress induced by toxicants such as DLD in the brain.

}, keywords = {Ashwagandha, Dieldrin, Glutathione, Malondialdehyde, Protein carbonyl}, doi = {10.4103/pr.pr_77_18}, author = {Tandra Ghosh and Sanvidhan G. Suke and Chandrashekhar Yadav and Rafat Ahmed and Basu Deb Banerjee} }