@article {1471, title = {GC-MS Analysis of an Ayurveda Formulation Erandamula Niruha Basti (Medicated Therapeutic Enema)}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {1071-1076}, type = {Original Article}, chapter = {1071}, abstract = {

Background: The scientific credibility of modern and Indian System of Medicine, such as Ayurveda and Siddha, is highly relevant in the current era. The gas chromatography-mass spectrometry (GC-MS) instrument separates chemical mixtures (the GC component) and identifies the components at a molecular level. Since Basti is the most effective remedy for Vata Dosha, it occupies a prominent position among the five Therapeutic measures of Panchakarma. Aim and Objectives: This study uses Gas Chromatography-Mass Spectrometry (GC-MS) analysis to examine the Erandamula Niruha Basti, with the goal of identifying links between its medicinal properties and the biomolecules it comprises. Materials and Methods: GCMS analysis was conducted using 7890 A GC with 5975C with a triple-axis detector. The compounds were identified after comparing the spectral configurations obtained with those of the available mass spectral database (NIST-08 SPECTRAL DATA). Results: Important compounds were found in the profile that resulted, showing the presence of some important molecules like 5-Acetoxymethyl- 2-furaldehyde,2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one,3-Furanmethanol, and furfural, which exhibit pharmacological actions like anti-inflammatory and antioxidant, which is in keeping with the therapeutic qualities that Eranndamoola Niruha Basti is said to possess. Conclusion: The current study uses GC-MS analysis to demonstrate the scientific validity of conventional formulations such as Erandamoola Niruha Basti. This Ayurvedic remedy{\textquoteright}s pharmacological claims are supported by the finding of important phytochemicals. Certain molecules, like furfural and 5-acetoxymethyl-2-furaldehyde, have antioxidant and anti-inflammatory qualities. These results are consistent with Basti{\textquoteright}s traditional therapeutic benefits in treating Vata disorders. The discovery of these biomolecules validates Erandamula Niruha Basti{\textquoteright}s function as a potent treatment for Vata vyadhi (musculoskeletal disorders) in Ayurveda.

}, keywords = {Anti-inflammatory, Basti, Erandamula niruha Basti, GCMS}, doi = {10.5530/pres.20252174}, author = {Anil Koralli and Pradeep L Gramapurohit and Sunil Jalalpure and Kshama Mutalik and Rashmi R} } @article {1463, title = {In vitro and Computational Studies of Compounds from Coleus amboinicus against Osteosarcoma}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {997-1004}, type = {Original Article}, chapter = {997}, abstract = {

Background: Osteosarcoma (OS) is among the most prevalent primary bone cancers, predominantly affecting children and adolescents. The average prevalent rate of osteosarcoma is 4.3 per million in males and 3.4 per million in females. Osteosarcoma poses diagnostic challenges due to the often-subtle clinical manifestations. Objectives: To investigate bioactive compounds in Coleus amboinicus Leaves (CAL) using computational methods and predict, their potential interactions with osteosarcoma cell surface receptors to explore therapeutic possibilities. Materials and Methods: The extract obtained from CAL was analyzed using a phytochemical assay, Fourier-Transform Infrared (FTIR) spectroscopy, and Gas Chromatography-Mass Spectrometry (GCMS). Molecular docking studies were conducted using Autodock to assess the interactions between the components of the extract and the cell surface receptors of osteosarcoma. The molecular docking experiments assessed the affinity of the phytochemicals to particular proteins that have a significant impact on the cell surface receptors of osteosarcoma. The pharmacokinetic characteristics of the drugs were assessed by examining their ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiles. Results: The computer study identified multiple phytochemicals derived from CAL with substantial binding affinity to the proteins of osteosarcoma cell surface receptors. These substances include beta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl, Hexanoic acid, 1-methylethyl ester, and Paromomycin. The ADMET analysis revealed that most of the discovered drugs possess favorable pharmacokinetic features and are anticipated to have low toxicity. Conclusion: Molecular docking revealed bioactive compounds with strong binding affinity to these receptors, indicating their potential inhibitory effects on cancer cell proliferation. Further research is required to provide comprehensive validation and clinical development.

}, keywords = {Bioactive compounds, GCMS, Molecular docking, Osteosarcoma, Phytochemical test, Plant extract}, doi = {10.5530/pres.20252178}, author = {Archana Behera and Raeesha Rahman and Benjamin Vinodh Joshua and Iadalin Ryntathiang and Monisha Prasad and Mukesh Kumar Dharmalingam Jothinathan} } @article {1365, title = {Unveiling the Quantitative and Qualitative Traits of Solar-Dried Indian Limonia acidissima Powder and its Therapeutic Findings}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {232-243}, type = {Original Article}, chapter = {232}, abstract = {

Background: Limonia acidissima is the only class of its type and an underused fruit in the Rutaceae family. Materials and Methods: The goal of the current study was to create powdered fresh and solar-dried wood apple and then analyze the physical, proximate, and trace mineral contents of each. The solar-dried powder had a relatively low moisture content (12.27\%) and high amounts of fat (8.53\%), protein (17.60\%), and carbohydrates (54.62\%). Results: The solar-dried powder showed noticeably greater trace mineral compositions. Nineteen bioactive compounds were identified using the GCMS examination; the most commonly discovered compounds were acetic acid, propanoic acid, octadecanoic acid, and N-hexadecanoic acid. The compounds exhibited strong antioxidant, antibacterial, and anti-inflammatory properties. The SEM-EDX analysis revealed seven elements, including C, O, Mg, P, Nb, Cl, and K, demonstrating the existence of significant compounds in the solar-dried powder. Carbonyl compounds, aldehydes, ketones, carboxylic acids, and esters, as well as aromatic compounds, methylene groups, methyl groups, esters, ethers, carboxylic acids, and alcohols, were found to have good biological qualities by FTIR analysis. Given that higher drying temperatures will hinder the components included in food, the study{\textquoteright}s conclusions indicate that solar drying is a fantastic technique to employ in the field of food technology today. Conclusion: Its many health advantages are a result of these ingredients. With its antibacterial qualities, the dried powder aids in the fight against bacterial and fungal illnesses. Additionally, it has hypoglycemic properties, which may help diabetics. Although further research is required in this area, the presence of bioactive chemicals in wood apple powder suggests possible anticancer effects. Gaining knowledge about the methods used to produce wood apple powder and its health-promoting qualities will help the food sector and help incorporate it into a balanced diet.

}, keywords = {EDX, FTIR spectra, GCMS, Proximate, Solar drying, Wood apple}, doi = {10.5530/pres.20252007}, author = {Raman Amardeepa and Poongodi Vijayakumar} }