@article {1489, title = {Evaluation of Anti-Depressant Activity of Garcinia cambogia Fruit Using Animal Models}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1214-1217}, type = {Original Article}, chapter = {1214}, abstract = {

Background: Garcinia cambogia fruit popularly specified as (Guttiferae) Clusiaceae has been used for variety of diseases. Depression is mental disorder which affects person day to day activities. Objectives: The main aim of this study is needed to assess the antidepressant activity of chloroform extract of Garcinia cambogia fruit using forced swim test in mice. Materials and Methods: Group I received control. Group 2 received standard drug Fluoxetine 20 mg/kg body weight. Group 3 and 4 received in doses 200 mg/kg and 400 mg /kg body weight of Garcinia cambogia fruit chloroform extract (P.O.) orally respectively. 60 min after the final dose of standard drug immobility period was recorded. Floating in water without swimming (immobility period) was recorded using a stopwatch. Results and Discussion: Garcinia cambogia chloroform extract at a concentration of 200 mg/kg and 400 mg/kg showed reduction in immobility period. In concentration of 400 mg/kg was found to exhibit significant antidepressant activity. Immobility period in seconds for 400 mg was found to be 187.8{\textpm}1.7 when compared with control of 217{\textpm}0.61. Conclusion: Reduction in immobility period is considered to have antidepressant effect on animal models. Therefore, chloroform extract of Garcinia cambogia indicates antidepressant potential. The outcome of the current study specify the Garcinia cambogia chloroform fruit extract contains xanthone as one phytochemical constituent which may be responsible to be functioning to show anti-depressant activity.

}, keywords = {Fluoxetine, Forced swim test, Garcinia cambogia fruits, Immobility period}, doi = {10.5530/pres.20252201}, author = {J. Priyadharisini and N. Savitha and Lydia Jeeboi Paramel} } @article {1297, title = {Exploring Antidepressant and Skeletal Muscle Relaxant Effects of the Hydroalcholic Extract of the Sedum lineare Thunb}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {803-809}, type = {Original Article}, chapter = {803}, abstract = {

Background: Sedum lineare is a perennial succulent plant that is a member of the family Crassulaceae. Objectives: The present study desired to explore the antidepressant and muscle relaxant activities of hydroalcoholic extract of Sedum lineare Thunb. Materials and Methods: Male Swiss Albino mice were selected and distributed on different groups and administered with extracts of various doses. The forced swim test, tail suspension test, grip strength test and inclined plane test were conducted. Results: The forced swim test showed a reduction in the immobility time, i.e., 124.6{\textpm}1.32, 98{\textpm}0.72 and 84.4{\textpm}1.20 at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg. The tail suspension test also presented reduced immobility time, i.e., 128{\textpm}1.61, 117.4{\textpm}0.96, 104.4{\textpm}0.63 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. The grip strength test showed a decrease in time to fall from the wire, i.e., 33.4{\textpm}0.92, 19.2{\textpm}0.86 and 15.2{\textpm}0.86 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Time in the inclined plane also reduced, i.e., 20.8{\textpm}1.24, 17.2{\textpm}0.58, 14.8{\textpm}1.06 in 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively. Conclusion: Hydroalcoholic extract of Sedum lineare Thunb possesses depression and muscle relaxant activities.

}, keywords = {Anti-depressant, Forced swim test, Muscle relaxant, Sedum lineare Thunb, Tail suspension test}, doi = {10.5530/pres.16.4.92}, author = {Sunil Kumar and Ajay Kumar Singh Rawat and Peeyush Bhardwaj} }