@article {1340, title = {Analytical Characterization of Achyranthes aspera L. Whole Plant}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {85-93}, type = {Original Article}, chapter = {85}, abstract = {

Background: The therapeutic properties of Achyranthes aspera have long been acknowledged and integrated into diverse traditional healthcare like Ayurvedic, Siddha, Unani and Naturopathic medicine for the management of various ailments. In ancient Indian systems of medicine such as Siddha and Ayurveda, the constituents found in this medicinal plant play a pivotal role in treating disorders. Both macro and micro elements are crucial components for plants to carry out their basic functions. Objectives: Consequently, the ash of Achyranthes aspera was analyzed chemically, with a focus on phytochemical and chromatographic analysis, along with spectral characterization of the entire plant, to determine the presence of inorganic constituents. Materials and Methods: Standard methods were followed for all physicochemical parameters. Chromatographic characterization was carried out using High Performance Thin Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC). Additionally, elemental characterization was performed using different instruments such as Energy Dispersive X-ray analysis (EDX), X-ray Fluorescence (XRF), Powder X-ray Diffraction (PXRD), X-ray Photoelectron Spectroscopy (XPS) and Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) to investigate the minerals present in the ash of Achyranthes aspera. Results: The HPTLC photo documentation revealed the presence of five spots at 254 nm and eight spots at 366 nm. Vanillin sulfuric acid reagent derivatization resulted in the appearance of 9 spots under white light. Furthermore, the HPLC chromatogram showed the separation of 13 peaks at 366 nm. The evaluation techniques also detected various elements such as Carbon (C), Oxygen (O), Sodium (Na), Magnesium (Mg), Aluminium (Al), Silicon (Si), Phosphorus (O), sulphur (S), Chlorine (Cl), potassium (K), Calcium (Ca), Manganese (Mn), Chromium (Cr), Iron (Fe) and Zinc (Zn). Conclusion: The analysis primarily focuses on quality control criteria and the mineral composition of the plant.

}, keywords = {Achyranthes aspera, ICP-OES, Nayurivi, PXRD, SEM-EDX, XPS, XRF}, doi = {10.5530/pres.20251928}, author = {Achintya Kumar Mandal and Saravanan Meenakshisundaram and Subashini Subramanian and Sujith Thatipelli and Rajesh Chandran and Shakila Ramachandran} } @article {1336, title = {Ethanolic Extract of aerial parts of Achyranthes aspera Attenuates Hepatotoxicity and Nephrotoxicity Induced by Cisplatin in Rat}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {60-69}, type = {Original Article}, chapter = {60}, abstract = {

Background: The chemotherapeutic agents used to treat cancer are known to possess potent adverse effects like nephrotoxicity and hepatotoxicity among others. Objectives: The aim of this current study happened to be the isolation of phytoconstituent from Achyranthes aspera and assess the protective effect of the compound against cisplatin-induced hepato- and nephrotoxicity in rats. Materials and Methods: Toluene: Ethyl Acetate (9:1) was used as the solvent system to isolate the phenolic compound from ethanolic extract of the leaves and stem of A. aspera. The isolated compounds were studied using mass spectroscopy, 1H NMR, FT-IR and UV. The effect of the isolated phenolic was assessed by study of various factors like body weight, organ weight, serum biomarkers and histopathological studies. Results: The treatment of cisplatin led to a significant increase the weight of the organs, hepatic and kidney biomarkers in serum suggesting toxicity whereas the the isolated component reversed the elevated levels (p\<0.05 compared to positive control). Conclusion: It could be concluded from the results that pretreatment with isolated component (coumarin) was able to attenuate the hepato-and nephron-toxicity induced by anticancer drug cisplatin.

}, keywords = {Achyranthes aspera, Cisplatin, Hepatotoxicity, Isolation, Nephrotoxicity}, doi = {10.5530/pres.20251905}, author = {Arijit Chaudhuri and Udichi Kataria and Anurag Dubey} } @article {1511, title = {Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1315-1327}, type = {Original Article}, chapter = {1315}, abstract = {

Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thoroughly explore Achyranthes aspera pharmacological potential. Materials and Methods: Antibacterial activity against a panel of bacterial strains was assessed using the disc diffusion method. To ascertain cell viability in cancer cell lines, anti-cancer activity was assessed using the MTT assay. The antioxidant activity of the plant extract was assessed by its capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Results: Achyranthes aspera extract showed encouraging antibacterial efficacy against specific bacterial strains, however not as strong as the common antibiotic, ciprofloxacin. The MTT assay indicated possible anti-cancer efficacy by showing a notable dose-dependent reduction in cancer cell lines{\textquoteright} cell viability. Through the scavenging of free radicals, the extract from Achyranthes aspera also demonstrated strong antioxidant activity. Conclusion: The pharmacological potential of Achyranthes aspera is strongly supported by this investigation, confirming its historic use in treating a variety of illnesses. Promising antioxidant, antimicrobial and anti-cancer properties were demonstrated by the plant extract. In order to determine the bioactive components, clarify the underlying mechanisms of action, assess the protection and efficacy of Achyranthes aspera extracts in preclinical, clinical contexts, these findings call for additional research.

}, keywords = {Achyranthes aspera, Anti-cancer, Anti-microbial, Antioxidant}, doi = {10.5530/pres.20252314}, author = {Arijit Chaudhuri and Biswajit Dash and Ashish Sarkar and Afrin Alam and Ayush Garg and Shivani Devi and Ankita Sharma and Varsha Chauhan and Tanbeer Kaur and Yashna Bawa} } @article {1257, title = {A Comprehensive Review of Ethnomedicinal, Phytochemical and Pharmacological Activity Profile of Achyranthes aspera}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {472-482}, type = {Review Article}, chapter = {472}, abstract = {

For centuries, humans have harnessed the healing properties of plants to address diverse health conditions. Ancient systems like Ayurveda and Unani medicine hold a rich repository of knowledge extolling the virtues of herbal remedies. Achyranthes aspera, one prolific native herbaceous plant in the South America, Asia and Africa often prospers as one common weed. Its many applications in traditional medicine for treating various diseases are at the heart of this global research. Achyranthes aspera is diverse many chemical ingredients, including terpenoids, alkaloids, steroids, saponins and flavonoids. This paper provides a thorough examination and elucidation of the phytochemical composition across different parts of Achyranthes aspera, delving into its traditional uses and expounding upon its pharmacological properties.

}, keywords = {Achyranthes aspera, Anti- microbial activity, anti-inflammatory activity, anti-oxidant, Antidiabetic activity}, doi = {10.5530/pres.16.3.57}, author = {Nem Kumar Jain and Shubham Anand and Priyanka Keshri and Santosh Kumar and Akshay Singh Sengar and Manoj Kumar Bajhaiya and Devendra Dhanorya and Sapna Yadav and Hema Katra and Sajal Mishra} }