@article {1334, title = {Antimicrobial Potential of Flavonoids (Free and Bound) of Euphorbia hirta against Selected Dermatophytes Strains}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {42-52}, type = {Original Article}, chapter = {42}, abstract = {

Background: Dermatophytosis/Tinea/ringworm is one of the most infectious diseases of humans, caused by invasion of stratum corneum by dermatophytic fungi viz. Trichophyton species, Microsporum species and Epidermophyton species, though not fatal infections are unpleasant, unhygienic to have and re-occurrence is very common. In recent years, especially during and after COVID 19 pandemic, the development of natural products to produce more cost-effective remedies for different diseases that are affordable to the common man is now being explored from plants. Euphorbia hirta of the family Euporbiaceae is well known for its medicinal properties in traditional and folklore medicinal systems. Euphorbia hirta possesses antifungal properties that may be effective against dermatophytic fungi responsible for causing ringworm. Materials and Methods: Different parts of the plant were taken for the extraction of flavonoids by a well-established protocol with some modifications. Agar well diffusion method, Two-fold dilution method and Total activity determination were carried out to establish the antidermatophytic activity of flavonoids from different parts of the plant Results: Significant Inhibition Zone (IZ) and Activity Index (AI) were observed against Microsporum canis, Trichophyton rubrum, and Epidermophyton floccosm from free flavonoid of the leaf; bound flavonoid of fruit; and bound flavonoid of the root. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) recorded were more or less similar to that of standard drugs. Conclusion: The present study suggests metabolite profiling of different parts of E. hirta. Flavonoids from the plant could be used as a source for the development of alternative drugs for the topical treatment of dermatophytosis.

}, keywords = {Dermatophytes, Euphorbia hirta, MFC, MIC, Skin disorders}, doi = {10.5530/pres.20251694}, author = {Bindu Sharma and Vijay Laxmi Songer and Vinay Kumar Meena} } @article {1112, title = {Photoprotective Activity of Plants Used for Skin Disorders by the Native Population from the Brazilian Amazon Basin: A Preliminary Study}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {112-118}, type = {Original Article}, chapter = {112}, abstract = {

Background: Sunscreens are essential in tropical countries with a high annual incidence of solar radiation. The incorporation of natural products in their formulations has great public acceptance and prevents several issues related to organic and inorganic filters, such as adverse reactions. The present study evaluates the antioxidant and photoprotective activities and the ability to inhibit tyrosinase of three plant species traditionally used by Amazonian inhabitants in the treatment of skin disorders. Materials and Methods: The antioxidant activity, the capacity to inhibit the enzyme tyrosinase, ratio UVA/UVB, critical wavelength, sun protection factor, and cellular viability was assessed in ethanolic extracts at 10\% of Chrysobalanus icaco, Kalanchoe pinnata, and Ayapana triplinervis collected in the State of Para-Brazil. Results: Chrysobalanus icaco and Kalanchoe pinnata showed promising antioxidant activity. Ayapana triplinervis demonstrated considerable inhibition of the tyrosinase enzyme. Plants extracts had low protection against UVB radiation, but adequate UVA protection. Ayapana triplinervis presented the lowest cellular viability of keratinocytes and murine fibroblasts. Conclusion: The addition of these extracts to other natural products with high sun protection factors can provide the consumer with a natural sunscreen.

}, keywords = {Antioxidant, Ayapana triplinervis, Chrysobalanus icaco, Depigmenting agent, Kalanchoe pinnata, Photoprotection, Skin disorders}, doi = {10.5530/097484900267}, author = {Thiago Portal and Margarete Tavares and Marcieni Ataide and Nadia Rezende Barbosa and Joseane R da Silva and Waldiney Pires Moraes and Jose Luiz Vieira} }