@article {1396, title = {Green Synthesis of Silver Nanoparticles from Secamone emetica: Characterization and Assessment of Antioxidant, Anti-Diabetic and Anti-Cancer Activities against MCF-7 Breast Cancer Cells}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {April 2025}, pages = {597-607}, type = {Original Article}, chapter = {597}, abstract = {

Background: Green-synthesized nanoparticles offer eco-friendly advantages over physical and chemical methods, utilizing plant extracts as natural capping, reducing and stabilizing agents. While Secamone emetica is renowned for its traditional medicinal applications, its potential in green nanoparticle synthesis remains unexplored, offering a promising avenue for research. Objectives: This study aimed to synthesize silver Nanoparticles (AgNPs) using aqueous leaf and stem extracts of Secamone emetica and evaluate their antioxidant, anti-diabetic and anti-cancer properties. Materials and Methods: The aqueous extracts of S. emetica Leaf (SL) and Stem (SS) were used for the green synthesis of AgNPs. The bio-reduction of silver ions by these extracts was validated through UV-visible spectroscopy, X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR). Antioxidant activities were evaluated using DPPH+ and ABTS˙+ radical scavenging assays. The anti-diabetic potential was evaluated through α-amylase and α-glucosidase inhibition assays. Cytotoxic effects on MCF-7 breast cancer cell lines were assessed at 100 μg/mL concentration. Results: SL-AgNPs exhibited higher antioxidant activity compared to SS-AgNPs in both DPPH+ and ABTS˙+ assays. In anti-diabetic assays, SL-AgNPs demonstrated 70.1\% α-amylase inhibition and 68.4\% α-glucosidase inhibition, outperforming SS-AgNPs, which showed 59.3\% and 57.6\% inhibition, respectively. In the anti-cancer assay, SL-AgNPs exhibited a cytotoxicity of 62.5\% against MCF-7 cells, whereas SS-AgNPs showed 50.8\% inhibition. Conclusion: These findings highlight the potential of green-synthesized SL-AgNPs and SS-AgNPs as effective antioxidant, anti-diabetic and anti-cancer agents.

}, keywords = {Anti-cancer, Anti-diabetic, Antioxidant activity, cytotoxicity, Secamone emetica, Silver nanoparticles}, doi = {10.5530/pres.20252064}, author = {S. Shalini and N. Sudeepthi and DH. Geetha and R. Jayashre} } @article {1202, title = {Estimation of Antidiabetic Trace Elements in Some Commonly Consumed Plants of West Bengal}, journal = {Pharmacognosy Research}, volume = {16}, year = {2023}, month = {December 2023}, pages = {67-71}, type = {Original Article}, chapter = {67}, abstract = {

Introduction: Trace elements are required by human body in very minute quantities for normal functioning of the body. They are necessary and essential for good health. Trace elements mainly act as cofactors to different enzymatic reactions. Abnormalities in trace element levels in human body can possibly lead to dysfunctions and disorders. Diabetes is a myriad of metabolic disorder characterized by hyperglycemia. Trace elements are involved in different processes in control of diabetes such homeostasis of glucose and regulation of insulin despite being a small part of living tissues. Objectives: The present work is focused on determining the amount of zinc, chromium and selenium content of leaves of some commonly consumed plants in the state of West Bengal by using Atomic Absorption Spectroscopy and understanding their role as an anti-diabetic agent. Plants having medicinal properties are used in treatment of large number of diseases, including metabolic and cardiovascular disorders. Materials and Methods: Two methods were used for digestion of plant samples: Wet oxidation and Dry ashing followed by AAS analysis. Conclusion: The study explored that Mentha spicata L. has maximum contribution to diabetes because of its significant content of anti-diabetic trace elements. The result can be useful for nutritional suggestion for diabetes patients as well as for the preparation of herbal formulation for diabetes mellitus in future.

}, keywords = {Anti-diabetic, Chromium, Selenium, Trace elements, Zinc}, doi = {10.5530/pres.16.1.9}, author = {Bhargab Sarma and Prerona Saha and Sourav Deka} } @article {1077, title = {A Current Pharmacological Impacts and Perspective of Hybanthus enneaspermus (Linn.) F. Muell}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {342-349}, type = {Review Article}, chapter = {342}, abstract = {

Medicine relies heavily on the use of medicinal plants. In terms of their pharmacology, they showed a broad spectrum of traits. All but a few of the medicinal plants in India are naturally rich in chemicals. An infinite number of potent phytochemicals can be synthesised by these plants. It is a tropical and subtropical shrub of the Hybanthus enneaspermus (L) famuell family. Asthma, cough, and epilepsy are all treated with the herb in ayurvedic literature as side effects of its usage. For steroids, sugars, alkaloids, polyphenols, catechins, tannins, anthraquinones, and amino acids, phytochemical analysis of Hybanthus enneaspermus achieved good quality. Alkaloids, terpenoids, tannins and glycosides are only some of the many phytochemical elements found in the plant. We examined the plant{\textquoteright}s phytopharmacological properties, including as anti-microbial and antioxidant properties as well as its effects on diabetes and arthritic conditions. We also looked at its anti-allergic and anti-convulsant properties. The active chemicals extracted from this valued herb have the potential to be used in drug development research because of the plant{\textquoteright}s wide range of pharmacological activity.

}, keywords = {Anti-allergic, Anti-arthritic, Anti-convulsant, Anti-diabetic, Anti-fertility, Anti-microbial, Antioxidant, Hybanthus enneaspermus}, doi = {10.5530/pres.14.4.51}, author = {Ananthapalpu Krishnan Nadar Ramya and Rengasamy Devika} }