@article {1511, title = {Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1315-1327}, type = {Original Article}, chapter = {1315}, abstract = {

Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thoroughly explore Achyranthes aspera pharmacological potential. Materials and Methods: Antibacterial activity against a panel of bacterial strains was assessed using the disc diffusion method. To ascertain cell viability in cancer cell lines, anti-cancer activity was assessed using the MTT assay. The antioxidant activity of the plant extract was assessed by its capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Results: Achyranthes aspera extract showed encouraging antibacterial efficacy against specific bacterial strains, however not as strong as the common antibiotic, ciprofloxacin. The MTT assay indicated possible anti-cancer efficacy by showing a notable dose-dependent reduction in cancer cell lines{\textquoteright} cell viability. Through the scavenging of free radicals, the extract from Achyranthes aspera also demonstrated strong antioxidant activity. Conclusion: The pharmacological potential of Achyranthes aspera is strongly supported by this investigation, confirming its historic use in treating a variety of illnesses. Promising antioxidant, antimicrobial and anti-cancer properties were demonstrated by the plant extract. In order to determine the bioactive components, clarify the underlying mechanisms of action, assess the protection and efficacy of Achyranthes aspera extracts in preclinical, clinical contexts, these findings call for additional research.

}, keywords = {Achyranthes aspera, Anti-cancer, Anti-microbial, Antioxidant}, doi = {10.5530/pres.20252314}, author = {Arijit Chaudhuri and Biswajit Dash and Ashish Sarkar and Afrin Alam and Ayush Garg and Shivani Devi and Ankita Sharma and Varsha Chauhan and Tanbeer Kaur and Yashna Bawa} } @article {1451, title = {GC-MS Analysis and in vitro Anti-Dandruff Activity of Phyla nodiflora against Malassezia furfur}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {909-913}, type = {Original Article}, chapter = {909}, abstract = {

Background: The common skin ailment known as dandruff mostly affects the scalp. It will impact nearly half of the prepubescent population, regardless of gender or race. The fungus Malassezia globosa, which is unique to the scalp, was found to be the causative culprit. The balloon vine, or Karnasphotha (Cardiospermum helicacabum Linn.), belongs to the Sapindaceae family and is traditionally used to treat dandruff. In vitro Antidandruff activity of Karnasphota Mula and Beeja by Agar cup method and Biocidal activity. Materials and Methods: Phyla nodiflora in vitro antidandruff activity using the Agar cup method and biocidal activity. Results: Phyla nodiflora demonstrated effective antidandruff properties against Malassezia furfur at varying concentrations. Conclusion: The Phyla nodiflora is having significant Antidandruff properties.

}, keywords = {Anti-microbial, Cup method, Dandruff, Ketoconazole, Malassezia furfur}, doi = {10.5530/pres.20252156}, author = {Priyanka Manmode and Dighe Santosh Bhausaheb} } @article {1515, title = {Isolation of Bioactive Metabolites from Tephrosia maxima and Tephrosia callophylla: A Phytochemical and Functional Study}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1341-1347}, type = {Original Article}, chapter = {1341}, abstract = {

Tephrosia maxima and Tephrosia callophylla, two lesser-studied members of the Fabaceae family, were evaluated for their phytochemical, pharmacological, and toxicological profiles in this study. Aqueous extracts from shade-dried leaves were subjected to SEM analysis, hemocompatibility testing, and assays for anti-bacterial, anti-cancer, anti-inflammatory, antioxidant, and general toxicity. SEM revealed irregular crystalline morphologies, indicative of diverse bioactive constituents. Both extracts exhibited \<2\% hemolysis, confirming systemic biocompatibility. Antibacterial activity against E. coli and S. aureus was evident, along with potent cytotoxicity against MCF-7 breast cancer cells. Anti-inflammatory and antioxidant assays demonstrated dose-dependent efficacy, with up to 80\% nitric oxide inhibition and 90\% DPPH radical scavenging. Toxicity studies using brine shrimp and zebrafish embryos showed high viability and minimal adverse effects. These findings highlight the therapeutic promise and biosafety of T. maxima and T. callophylla, supporting their potential for drug discovery and biomedical applications. Further studies are needed to isolate active compounds and elucidate molecular mechanisms.

}, keywords = {Anti-cancer, Anti-microbial, Photochemical, Tephrosia}, doi = {10.5530/pres.20250024}, author = {Anoop Kumar and Abilasha Ramasubramanian and Priyadharshini Muthumanickam and Bargavi Purushothaman} } @article {1249, title = {Unveiled the Pharmacological Attributes of Pupalia lappacea: An Unexplored Plant}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {449-456}, type = {Review Article}, chapter = {449}, abstract = {

Introduction: Pupalia lappacea which is commonly referred to as forest burr found everywhere in the world. In this review article, we will discuss the traditional use and photochemistry of plants. Its traditional uses have been investigated by various scientists whose results came out to be effective against various diseases. Pupalia lappacea consists of various phytochemicals named stearic acid, stigmasterol, formic acid, 1-methyl ethyl ester, etc. In vitro and in vivo studies that have been investigated thus far prove that this plant posse{\textquoteright}s great therapeutic potential including anti-microbial, antioxidant, anti-inflammatory, anti-diarrheal, anti-nociceptive and anti-pyretic, anti-plasmodium, anti-hypolipidemic, antidiabetic activity which can be further explored for its clinical utility. Materials and Methods: This article comprises data from a research article published on various search engines including Google Scholar, PubMed, ScienceDirect, Scopus, etc., Data is also collected via textbooks, reference books, review papers and ancient texts. Objectives: This review aims to gather all updated pharmacological investigations that have been done on Pupalia lappacea together. In short, the main aim was to provide an updated review of Pupalia lappacea to the researchers who further want to explore its potency and efficacy. Results: All the documents related to the plant were studied thoroughly and it was concluded that this plant possesses a great therapeutic potential and can be clinically explored.

}, keywords = {Anti-inflammatory, Anti-microbial, Antioxidant, Phytoconstituent, Pupalia lappacea}, doi = {10.5530/pres.16.3.54}, author = {Poonam Dorata and Harsh Goswami and Pooja and Tarun Kumar and Manisha Pandey} } @article {1077, title = {A Current Pharmacological Impacts and Perspective of Hybanthus enneaspermus (Linn.) F. Muell}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {342-349}, type = {Review Article}, chapter = {342}, abstract = {

Medicine relies heavily on the use of medicinal plants. In terms of their pharmacology, they showed a broad spectrum of traits. All but a few of the medicinal plants in India are naturally rich in chemicals. An infinite number of potent phytochemicals can be synthesised by these plants. It is a tropical and subtropical shrub of the Hybanthus enneaspermus (L) famuell family. Asthma, cough, and epilepsy are all treated with the herb in ayurvedic literature as side effects of its usage. For steroids, sugars, alkaloids, polyphenols, catechins, tannins, anthraquinones, and amino acids, phytochemical analysis of Hybanthus enneaspermus achieved good quality. Alkaloids, terpenoids, tannins and glycosides are only some of the many phytochemical elements found in the plant. We examined the plant{\textquoteright}s phytopharmacological properties, including as anti-microbial and antioxidant properties as well as its effects on diabetes and arthritic conditions. We also looked at its anti-allergic and anti-convulsant properties. The active chemicals extracted from this valued herb have the potential to be used in drug development research because of the plant{\textquoteright}s wide range of pharmacological activity.

}, keywords = {Anti-allergic, Anti-arthritic, Anti-convulsant, Anti-diabetic, Anti-fertility, Anti-microbial, Antioxidant, Hybanthus enneaspermus}, doi = {10.5530/pres.14.4.51}, author = {Ananthapalpu Krishnan Nadar Ramya and Rengasamy Devika} }