@article {113, title = {An Open-Label, Multi-Center, Prospective, Interventional, Clinical Study to Evaluate the Efficacy and Safety of Ayuvigo Forte Capsules in Patients Suffering from Oligospermia}, journal = {Pharmacognosy Research}, volume = {11}, year = {2019}, month = {August 2019}, pages = {290-294}, type = {Original Article}, chapter = {290}, abstract = {

Background: Oligospermia refers to semen with a low concentration of sperms. Oligospermia is one of the common causative factors of male infertility. Objectives: The objective of this study was to assess the efficacy and safety of Ayuvigo forte capsule in patients suffering from oligospermia. Materials and Methods: This was an open-label, prospective, interventional, multi-center clinical study. A total of 30 patients were completed the study. All patients were advised to consume two Ayuvigo forte capsules twice daily orally after meals with a cup of milk for 90 days. Data describing quantitative measures are expressed as a mean {\textpm} standard deviation. Results: The mean total sperm count, mean progressive sperm motility, and total number of spermatozoa increased significantly (P \< 0.05) by 90.54\%, 33.65\%, and 98.88\% at the end of the study, respectively. Most patients had shown significant (P \< 0.05) improvement in subjective parameters of low sperm count assessed as per Ayurveda. Furthermore, significant (P \< 0.05) improvement was observed in mean serum free testosterone level. No statistically significant (P \> 0.05) changes were observed in mean serum luteinizing hormone, follicle-stimulating hormone, prolactin, safety laboratory parameters, and vitals. Excellent overall efficacy and tolerability were observed in majority of patients. Conclusion: Ayuvigo forte capsule is safe and effective for the management of oligospermia.

}, keywords = {Ayuvigo forte capsule, Oligospermia, Sperm count, Sperm motility, Testosterone level.}, doi = {10.4103/pr.pr_158_18}, author = {Sanjay M. Tamoli and Narendra B. Mundhe and Devdatta A. Deshmukh and Shishir Purushottam Pande and Rahul Ramkrushna Kamde and Vidyadhar S. Kumbhar and Sachin Anil Upasani and Swapnali B. Mahadik} } @article {896, title = {Effects of the Oral Administration of Nonpolar Extract from Ardisia squamulosa Presl (Myrsinaceae) Leaves on Spermatogenesis in Rats}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {November,2011}, pages = {260-265}, type = {Original Article}, chapter = {260}, abstract = {

Background: Several Ardisia species have been found to possess numerous bioactivities but their reproductive toxicity has been poorly explored. In the present study, the effects of the leaf hexane extract of Philippine indigenous Ardisia squamulosa on epididymal sperm count, \%viability and \%aberration of sperms and weights of seminal vesicle, cauda epididymis, and testes in addition to the weights of liver, kidney, and body were evaluated. Methods: The extracts at daily dose levels of 1, 10, and 100 mg/Kg BW in 10\% polysorbate-80 in corn oil were administered by gavage for 8 successive days to 8-10 weeks old male SD rats and sacrificed after 9 days. Daily body weights and final organ weights were measured. Sperm from the cauda epididymis was extracted and measured according standard sperm parameters (sperm count, morphology, viability and membrane integrity). Results: Significant findings were the decline of left epididymal sperm count to testis weight ratio and increase in \%sperm morphological aberration from both cauda epididymis obtained with the 10 mg/Kg BW dose. Conclusion: The hexane extract from Ardisia squamulosa had significant effect on sperm count but with negligible effect on sperm morphology and viability.

}, keywords = {Myrsinaceae, Sperm count, Sperm morphology, Spermatogenesis}, doi = {10.4103/0974-8490.89747}, author = {Dennis D. Raga and Glorina N. Pocsidio and Annabelle A. Herrera} }