@article {1104, title = {Phytotherapeutic Potential of Natural Herbal Medicines for Management of Psoriasis: Current Status}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {42-55}, type = {Review Report}, chapter = {42}, abstract = {

Psoriasis is a complex multifunctional inflammatory autoimmune skin disease, which is mainly characterized by activation of T-cell (T-lymphocyte), abnormal proliferation keratinocyte, local vascular changes and activation of the neutrophil. A number of therapies are being used to treat psoriasis including topical, systemic and phototherapy recpectively but none of them is able to cure the disease completely, precluding the long-term serious side effects for the human body. In contrast to these, herbal therapies can play an important role for treatment of psoriasis. With this endeavor, this review reports the recent developments and patent showing potential of herbal therapy for treatment of psoriasis along with future prospect in the field of traditional and novel drug delivery system (NDDS) for treatment of psoriasis.

}, keywords = {Herbal drug, Hyperproliferation, Keratinocyte, Novel drug delivery systems, Psoriasis}, doi = {10.5530/097484900261}, author = {Nupur Maheshwari and Neelesh Maheshwari and Dinesh Kumar Mishra and Anju Goyal} } @article {108, title = {Gas Chromatography-Mass Spectrometry Elucidation and Antipsoriatic Activity on Developed Herbal Formulations from Carissa congesta, Catharanthus roseus, Annona squamosa, and Polyalthia longifolia Plant Extracts}, journal = {Pharmacognosy Research}, volume = {12}, year = {2020}, month = {May 2020}, pages = {163-168}, type = {Original Article}, chapter = {163}, abstract = {

Background: Annonaceae and Apocynaceae families are known for their plethora of pharmacotherapeutic potential. Objectives: To evaluate antipsoriatic potential (ultraviolet [UV]-induced photodermatitis and tail model) and gas chromatography-mass spectrometry (GC-MS) studies on developed formulations from the plant extracts. Materials and Methods: Formulations of ethanolic extracts of Carissa congesta and Catharanthus roseus and petroleum ether extracts of Annona squamosa and Polyalthia longifolia were evaluated for antipsoriatic activity (UV-induced photodermatitis and tail model) at 250 and 500 mg/ kg. GC-MS studies were done subsequently after 6 months. Formulation batches were tested by different tests, viz., pH, viscosity, spreadability, washability, homogeneity, grittiness, drug content, Sudan red, bleeding, and sensitivity tests. Results: Histopathology studies indicated the absence of Munro{\textquoteright}s microabscess, regular elongation of rete ridges, capillary loop dilatation, granular cell layer, and prominent parakeratosis at 500 mg/kg. Formulations of the plant extracts did not reveal toxic components by GC-MS interpretation. No greasiness was observed during washing. Uniform homogeneity was observed with neither clumps nor large aggregates. The dispersed globules appeared red against colorless water background. Bleeding time was found to be stable during the experimentation. Conclusion: Developed topical plant formulations showed antipsoriatic potential on selected models. The GC-MS studies confirmed the presence of no drastic changes in the quantity of active constituents assuring its stability.

}, keywords = {Annona squamosa, Carissa congesta, Catharanthus roseus, Gas chromatography-mass spectrometry, Polyalthia longifolia, Psoriasis}, doi = {10.4103/pr.pr_110_19}, author = {Bernadette Donald Matthews and Ankita Sajeev Patil and Gaurav Mahesh Doshi} } @article {474, title = {A Clinico-analytical Study on Seed of Wrightia antidysenterica Linn. as a Therapeutic Emetic Agent (Vamaka Yoga) in the Management of Psoriasis}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {March 2016}, pages = {19-25}, type = {Original Article}, chapter = {19}, abstract = {

Objectives: Wrightia antidysenterica Linn. (WA) is male variety Kutaja stated to be potent therapeutic emetic agent in skin disorders. Expulsion of doshas through oral route is termed as Vamana Karma (VK) (therapeutic emesis). However, so far, its utility for Vamana is not explored in detail, therefore there is a need to revalidate the utility of WA for Vamana. Hence, the above study was conducted to ascertain the efficacy as a therapeutic emetic agent (vamaka yoga) in the management of psoriasis along with quality control and standardization of this herb. Materials and Methods: The drug was standardized as per analytical procedures in Pharmacopeias. Thirty patients of psoriasis fulfilling inclusion criteria were taken for the study and Vamana with WA was conducted. Criteria were prepared to assess the signs and Symptoms of psoriasis. VK was assessed using the classical Lakshanas (features) such as Anthiki shudhi (Ending symptoms of emesis), Vaigiki shudhi (features of vomiting bouts), Maniki shudhi (Quantitative and qualitative purification), complications. Result: VK with WA showed significant relief in parameters of psoriasis such as scaling, itching, candle grease sign (P \< 0.001), and psoriasis area and severity index score (P = 0.001). In VK with WA, mean number of Vegas (vomiting bouts) was 6.91. 66\% patients showing quantitative purification between 301 and 600 ml. 73.33\% showed all Symptoms of purification. 73.33\% patients showed Kaphanta vamana (Moderate expulsion of desire humor). In the level of biopurification, 66.66\% patients showed moderated purification. No complication was noted with moderate drug palatability. Conclusion: Pharmacopeial analytical study showed its standardized values for testing the drug used for the study. It is proved as potent therapeutic emetic agent with no complication showed its clinical benefits over skin disorder like psoriasis.

}, keywords = {Kutaja beej, pharmacopeial analysis, Psoriasis, therapeutic emesis, vamana}, doi = {10.4103/0974-8490.178641}, author = {Nirupam Bhattacharyya and Muralidhar P. Pujar and Ashutosh Chaturvedi and M. Ashvini Kumar and B. A. Lohith and K. N. Sunil Kumar} }