@article {912, title = {Development and Evaluation of Formulations of Microbial Biotransformed extract of Tobacco Leaves for Hair Growth Potential}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {November 2010}, pages = {300-303}, type = {Original Article}, chapter = {300}, abstract = {

Background: Extensive researches are going on to explore the effective and safe drug for their hair growth. Tobacco leaves are traditionally known to potentiate hair growth promotion. Therefore, the aim of present study was to formulate and evaluate the microbial biotransformed extract of tobacco leaves for hair growth potential in male albino wister rats. Materials and Methods: The extract of was prepared by microbial biotransformation of tobacco leaves in cow urine for 28 days. The herbal formulations (lotion) were formulated by general method using o/w type base in various rations or concentrations such as 10\%, 20\% and 30\% of extract. These lotions were applied on shaved skin area of rats for 30 days once in a day and hair length, serum total protein, and total testosterone were measured. Results: Our formulations show increase in hair growth and serum total protein at concentration dependent manner with effect to standard and control groups. Serum total testosterone decreases according to a concentration dependent manner. Conclusion: Further, series of investigations are, however, necessary to remain exploration, which includes their structural elucidation, characterization, clinical safety, reliability and molecular mechanism involved in this pharmacological activity.

}, keywords = {Alopecia, Hair growth, Tobacco leaves}, doi = {10.4103/0974-8490.72328}, author = {Ashlesh V Murkute and Mahesh S Sahu and Prashant Y Mali and Vinod D Rangari} } @article {837, title = {Development and Evaluation of Polyherbal Formulations for Hair Growth Potential}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {234-237}, type = {Original Article}, chapter = {234}, abstract = {

The present study is an effort to formulate and evaluate hair growth promoting activity of three polyherbal formulations. Polyherbal formulations were prepared using extract of Cicer arietinum Linn., Ocimum sanctum Linn. and Cyperus rotundus Linn. in various ratios to obtained the best formulation The extract incorporated into cream were applied topically on shaved skin of rats and primary skin irritation test, hair growth initiation time, completion time, hair length and diameter were recorded. The ratio of Cicer arietinum Linn., Ocimum sanctum Linn. and Cyperus rotundus Linn. in 1:2:3 showed excellent hair growth activity comparable to standard.

}, keywords = {Alopecia, Hair growth, Herbal formulation, Polyherbal}, doi = {Nil}, author = {Rathi Vaishali and Rathi Jagdish Chandra and Tamizharasi Sengodan} }