@article {1481, title = {Accelerated Stability Study of Powder Formulation Safoof Muqliyasa and Safoof Mulayyin}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1253-1273}, type = {Original Article}, chapter = {1253}, abstract = {

Background and Objectives: Evaluation of stability studies of Unani Medicine (UM) formulations determined on the basis of scientific data are the need of the time and also recommended in D and C Act. There is immense need to evaluate precise shelf life for each powder formulations. Materials and Methods: Accelerated Stability Study (ASS) of Safoof Muqliyasa (S. Muq) and Safoof Mulayyin. (S. Mul) was carried out with at elevated temperature and humidity conditions 40{\textordmasculine}C{\textpm}2{\textordmasculine}C with Relative Humidity of 75\%{\textpm}5\% RH according to ICH guidelines, by keeping in stability chamber in containers used by commercial UM. Pharmacy{\textquoteright}s (i.e. sealed HDPE containers). Testing frequency of samples was 0, 3 and 6 months and was subjected to various organoleptic, physical, microbiological and chemical tests parameters with HPLC quantification of active constituents/markers (Chebulic acid in S. Muq and Gingerol in S. Mul). Results were accessed as per API guidelines and are also statistically analyzed for 10\% degradation, from liner regression equation using individual slope and Intercept. Results: Both S. Muq and S. Mul were suitable at accelerated condition upto 3 month storage on selected physical, microbiological and chemical parameters as per API evaluation guidelines, and it can be extrapolated that real time shelf life period (predicted stability) according to Grimm{\textquoteright}s statement, for zone III and IV, 3.3 as 10 month at room temperature and packaging method adopted in the study and by 10\% degradation in different parameters by multiplying factor of 3.3 accelerated stability of Safoof Muqliyasa can be extrapoled as 2 years and 1 month and for Safoof Mulayyin 1 year and 5 months. Conclusion: According to physical and microbiological parameters both S. Muq and S. Mul are stable for 6 months in ASS but changes in selected chemical parameters was observed for after 3rd month making it stable approximately for 1 year. Stability of salt containing S. Mul was found to be comparatively lower than the non-salt containing S. Muq This observation/ shelf life may be exclusive to both the powders.

}, keywords = {Accelerated stability study, Powder, Safoof Mulayyin, Safoof Muqliyasa, Stability, Unani}, doi = {10.5530/pres.20252160}, author = {Md Naquibuddin and Hamiduddin and Gazi Jahangeer Rather and Fakeha Firdous Khanbhadur and Mohammed Saad} } @article {1106, title = {Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {December 2022}, pages = {64-70}, type = {Original Article}, chapter = {64}, abstract = {

Aim: The present research aimed to formulate a transdermal patch incorporating herbal bioactive Vitex negundo extract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer. Materials and Methods: Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch. Results: The in vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15\%, 87.12\%, 82.34\%, 92.45\%, 86.78\% and 76.21\% at 8hr. The order of drug release was found to be F4\>F1\>F2\>F3\>F6\>F5. Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactive Vitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

}, keywords = {Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR)., Physico-chemical properties, Stability, Transdermal, UV/Vis Spectroscopy}, doi = {10.5530/097484900244}, author = {Poojashree Verma and Neelesh Maheshwari and Deepika Bairagee} } @article {815, title = {Evaluation of Extracts of Piper Sarmentosum for Accelerated Stability by Metabolomic Fingerprint Profiling}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {185-191}, type = {Original Article}, chapter = {185}, keywords = {Metabolomic Fingerprint profiling, Piper sarmentosum, Piperaceae, Stability}, doi = {Nil} }