@article {1082, title = {Development of a Gastroretentive Polyherbal Formulation and its Standardization}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {379-390}, type = {Original Article}, chapter = {379}, abstract = {

Background: Phytopharmaceuticals within the shape of the entire herb, plant parts, or separated bioactive constituents have been utilized broadly in therapeutics since antiquated times till date. The appealing use of drugs of the natural root has driven the requirement for standardization as per the WHO guidelines. Objectives: The main aim of the existing study was to formulate polyherbal gastroretentive capsules by using Carbopol 934 and 971P in different concentration ranges to get desired buoyancy rate. Materials and Methods: The prepared formulation was characterized by physico-chemical parameters and pharmaceutical quality control tests. Standard procedures were used to estimate the organoleptic properties, extractive values, and ash values of the crude drugs used in formulations. Extraction was carried out using Soxhlation followed by preliminary phytochemical evaluation and HPTLC fingerprinting of the extracts. The extracts were formulated into a gastroretentive polyherbal capsule and assessed for physical parameters. Results: The phytochemical assessment established the presence of flavonoids, alkaloids, saponins, steroids, and glycosides. Rf values obtained from the HPTLC studies of the extracts signified the presence of important phytoconstituents such as Shogaols, 6-Gingerol, 8-Gingerol, Glycyrrhizin, Andrographolides, Marmelosin, and Conessine. Percent Carr{\textquoteright}s consolidation index ranging from 8.111 {\textpm} 0.157 to 8.827 {\textpm} 0.186, Hausner{\textquoteright}s ratio between 1.088 {\textpm} 0.002 to 1.097 {\textpm} 0.002, and angle of repose below 30 are indicative of excellent flow property of the granules. Conclusion: The gastroretentive capsules PHF4 containing granules formulated using 75 mg Carbopol 971P showed a buoyancy effect of more than 24 hr with desired structural integrity.

}, keywords = {Extraction, HPTLC fingerprinting, Polyherbal formulation, Standardization}, doi = {10.5530/pres.14.4.56}, author = {Manish Kumar Gupta and Medha Amol Khade and Birendra Srivastava and Supriya Rajesh Hyam and Prashant Basappa Gurav} } @article {759, title = {Standardization of some herbal antidiabetic drugs in polyherbal formulation}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {April 2011}, pages = {49-56}, type = {Original Article}, chapter = {49}, abstract = {

Background:\ Ayurvedic formulations are used to treat a wide variety of diseases including diabetes mellitus Standardization of herbal formulation is essential in order to assess the quality of drugs. The present paper reports standardization of eight herbal anti-diabetic drugs-Momordica charantia\ (seeds),\ Syzigium cumini\ (seeds),\ Trigonella foenum\ (seeds),\ Azadirachta indica\ (leaves),\ Emblica officinalis\ (fruits),\ Curcuma longa\ (rhizomes),\ Gymnema sylvestre\ (leaves),\ Pterocarpus marsupium\ (heart-wood) individually and in polyherbal marketed samples of Baidyanath Madhumehari Churna\ Material and Methods:\ Shivayu Madhuhari Churna, Meghdut Madhushoonya Churna and were compared to the in-house preparation for physicochemical properties.\ Results and Conclusions:\ The limits obtained from the different physicochemical parameters of the individual eight herbal drugs and the marketed formulations could be used as reference standard for standardization of the anti-diabetic drugs in a quality control laboratory.

}, keywords = {Herbal antidiabetic drugs, Physicochemical parameters, Polyherbal formulation, Standardization}, doi = {10.4103/0974-8490.79116}, author = {Harinarayan Singh Chandel and AK Pathak and Mukul Tailang} } @article {797, title = {Standardization of Ajmodadi churna, a Polyherbal Formulation}, journal = {Pharmacognosy Research}, volume = {2}, year = {2010}, month = {May 2010}, pages = {98-101}, type = {Original Article}, chapter = {98}, abstract = {

Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles. This article reports on standardization of Ajmodadi churna, a polyherbal ayurvedic medicine used as a carminative and an antispasmodic, and is a strong wormifuge, and helps in all painful conditions like sciatica and stiffness in back and also restores normal digestive functions. Ajmodadi churna was prepared as per Ayurvedic Formulary of India. In-house preparation and the marketed drug have been standardized on the basis of organoleptic characters, physical characteristics, and physico-chemical properties. The set parameters were found to be sufficient to evaluate the churna and can be used as reference standards for the quality control/quality assurance laboratory of a Pharmaceutical house.

}, keywords = {Ajmodadi churna, Physico-chemical, Polyherbal formulation, Standardization}, doi = {10.4103/0974-8490.62957}, author = {Neeraj K Sriwastava and CS Shreedhara and HN Aswatha Ram} } @article {829, title = {Standardisation of Avipattikar Churna- A Polyherbal Formulation}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {224-227}, type = {Original Article}, chapter = {224}, abstract = {

Standardisation of herbal formulation is essential in order to assess the quality of drugs, based on the concentration of their active principles. The present paper reports on standardisation of Avipattikar churna, a poly herbal ayurvedic medicine used as remedy for acidity and complications associated with it like headache, nausea and vomiting. It is also used as laxative and helps to increase appetite. Avipattikar churna was prepared as per Ayurvedic Formulary of India. In-house preparation and two marketed have been standardised on the basis of organoleptic characters, physical characteristics and physico-chemical properties. The set parameters were found to be sufficient to evaluate the churna and can be used as reference standards for the quality control/quality assurance laboratory of a Pharmaceutical house.

}, keywords = {Avipattikar churna, Physicochemical parameters, Polyherbal formulation, Standardisation}, doi = {Nil}, author = {Aswatha Ram HN and Kaushik Ujjwal and Lachake Prachiti and Shreedhara CS} }