@article {657, title = {Anti-ulcer and Ulcer Healing Potentials of Musa Sapientum Peel Extract in the Laboratory Rodents}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {173-178}, type = {Original Article }, chapter = {173}, abstract = {

Background:\ This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of\ Musa sapientum\ peel in the laboratory rats.\ Materials and Methods:\ Methanol extract of the peels on\ Musa sapientum\ (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats.\ Results:\ The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P\ <= 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group.\ Conclusion:\ The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

}, keywords = {Anti-ulcer, Musa sapientum, Peptic Ulcer, Ulcer Healing}, doi = {10.4103/0974-8490.112423}, author = {Samuel Adetunji Onasanwo and Benjamin Obukowho Emikpe and Austin Azubuike Ajah and Taiwo Olayemi Elufioye} } @article {714, title = {Anti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals}, journal = {Pharmacognosy Research}, volume = {3}, year = {2011}, month = {April 2011}, pages = {02-08}, type = {Original Article}, chapter = {02}, abstract = {

Background:\ The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of\ Lagenaria breviflora\ (EELB) whole fruit in laboratory rats.\ Methods:\ The anti-ulcer property of the ethanolic extract of the whole fruit of\ Lagenaria breviflora\ (LB) was assessed using the cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) gastric ulcer models. The scavenging activity of the LB extract was examined with 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and Superoxide anion scavenging models.\ Results:\ EELB (50, 100, 150 and 200 mg/kg, b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or Suscralfate (500 mg/kg b.w.), respectively. The\ in vitro\ antioxidant activity of LB was demonstrated by its ability to quench free radicals generated by nitric oxide and superoxide anion with a concomitant scavenging potential against DPPH-induced radical formation.\ Conclusion:\ Taken together, the study showed that the whole fruit extract possess potent anti-ulcer and antioxidant activities.

}, keywords = {Anti-ulcer, Antioxidant, free radical scavenger}, doi = {10.4103/0974-8490.79108}, author = {SA Onasanwo and Neetu Singh and AB Saba and AA Oyagbemi and OA Oridupa and Gautam Palit} } @article {852, title = {Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C}, journal = {Pharmacognosy Research}, volume = {1}, year = {2009}, month = {January 2010 }, pages = {250-255}, type = {Original Article}, chapter = {250}, abstract = {

Ardisia crispa Thunb D.C (Myrsinaceae), has long been used in treating various ailments among the local villagers. The objective of this study was to investigate experimentally the possible anti-ulcer activity of Ardisia crispa. The effect of hexane fraction of root of Ardisia crispa (ACRH) was evaluated in experimental ulcer models with necrotizing agents ie ethanol, NaCl, HCl, NaOH and also COX-1 inhibitor namely indomethacin as inducers. Four doses ie 10, 30, 100 and 300 mg/kg were selected for further study. Ulcer effects were determined by counting the total surface area of lesion in mm2. Results showed that ACRH provided significant protection in various experimental models used. Pretreatment with ACRH at all doses (10,30,100 and 300 mg/kg) has produced significant inhibition of gastric mucosal damage induced by 80\% EtOH and 25\% NaCl, whilst at 30, 100 and 300 mg/ kg, ACRH significantly reduced the lesion formation in ulcer induced by 0.6 M HCl, 0.2 M NaOH and 30 mg/kg indomethacin. The present study indicates that the hexane fraction of Ardisia crispa (ACRH) exhibits significant anti-ulcer effect.

}, keywords = {Anti-ulcer, Ardisia crispa, Ethanol-induced ulcer, Indomethacin{\textendash}induced ulcer, Necrotizing agents}, doi = {Nil}, author = {Roslida A.H and Teh Y.H and Kim K.H} }