@article {1330, title = {HRLC-MS Metabolite Profiling and Evaluation of Analgesic and Anti-inflammatory Activity of Ficus nervosa Heyne ex Roth}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {192-200}, type = {Original Article}, chapter = {192}, abstract = {

Background: Medicinal plants are one of the major sources for the development of new drugs, which creates the interest on searching biologically active molecules from the medicinal plants. Medicinal plants have been used as folkloric medicine for decades. The medicinal plant Ficus nervosa used in the Eastern Ghats for various health care preparations. However, the plant has not been scientifically validated with concern to the pharmacological aspects to undertake the current study. Objective: The study aimed to identification of phytoconstituents from Ficus nervosa leaves extract and exploring the analgesic and anti-inflammatory effects. Materials and Methods: The phytoconstituents were analysis through LCMS/MS method. Further, extract activity was evaluated using tail flick, hot plate and acetic acid-induced writhing methods. Results: The study identified top 20 compounds (10 from each +ve and -ve mode analysis). The extract found to be safe up to 2000 mg/kg and there were no mortalities were observed. In contrast, the NM extract showed anti-inflammatory effect at the dose of 500 mg/kg compared to reference compound. The NM dose 500 mg/kg showed a significant analgesic effect with a maximum latency response and inhibition of acetic acid-induced writhing. Conclusion: These study findings suggest that Ficus nervosa may have potential analgesic and anti-inflammatory activity meriting further biological evaluations.

}, keywords = {Acetic acid induced writhing response, Carrageenan-induced paw edema method, Ficus nervosa leaves, Hot Plate, Tail flick}, doi = {10.5530/pres.20251987}, author = {Sailaja Nambaaru and Kancharla Bhanukiran} } @article {648, title = {Evaluation of Marine Brown Algae Sargassum ilicifolium Extract for Analgesic and Anti-inflammatory Activity}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {May 2013}, pages = {146-149}, type = {Original Article }, chapter = {146}, abstract = {

Background\ : The methanolic extract of\ Sargassum ilicifolium\ (Pheophyceae) was used to evaluate its analgesic and anti-inflammatory activity in the present study.\ Materials and Methods:\ Analgesic activity was tested using Acetic acid writhing method and Eddy hot plate method in Male albino mice and Wister rats respectively at a dose level of 1, 10, 50, 100mg/kg p.o. At the same dose, its anti-inflammatory activity was also tested using Carrageenan induced rat paw edema method Result Acetic acid writhing test and Eddy{\textquoteright}s hot plate episodes were significantly and dose dependently reduced. Carrageenan (a standard inflammatory agent) induced paw edema in rats was significantly reduced after intraperitonal administration of methanolic extract.\ Results:\ showed dose dependant significant activity in comparison with standard and control.\ Conclusion:\ Methanolic extracts of the brown seaweeds\ Sargassum ilicifolium\ have potent analgesic and anti-inflammatory activity at moderate doses.

}, keywords = {Acetic acid Writhing, Analgesic, Anti-inflammatory, Carrageenan, Granuloma, Hot Plate, Paw edema, Sargassum Ilicifolium}, doi = {10.4103/0974-8490.112413 }, author = {Chandraraj C Simpi and Channabasappa V Nagathan and Santosh R Karajgi and Navanath V Kalyane} }