@article {1321, title = {Evaluating the Efficacy of a Ginger Extract-Infused Mustard Oil Transdermal Patch for Arthritis Management}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {October 2024}, pages = {935-942}, type = {Original Article}, chapter = {935}, abstract = {

Aim: The aim of this study is to develop and characterize a novel herbal transdermal patch containing mustard oil and ginger extract for the management of arthritis, addressing the significant pain and reduced quality of life associated with this chronic inflammatory condition. Materials and Methods: Various extraction methods, including water, alcohol, and mustard oil extraction, were employed to obtain ginger extract. These extracts underwent initial evaluation and subsequent in vitro anti-inflammatory testing. Transdermal patch formulations were developed using the oil-based ginger extract, with naproxen incorporated as a model drug. Parameters such as weight variations, folding endurance, tensile strength, and moisture content were rigorously assessed. In vitro drug permeability tests and ex vivo permeation tests were conducted to evaluate drug release characteristics, with Rhodamine B/Oil Red O Dye used as a tracer. Results: Water-extracted ginger showed reduced potency on the 14th day with some fungal growth, while the alcohol extract exhibited lower efficacy compared to the oil extract. Six distinct transdermal patch formulations were developed, with parameters such as weight variations, folding endurance, tensile strength, and moisture content meeting specified criteria. In vitro drug permeability tests and ex vivo permeation tests revealed a drug release range of 0.1 to 0.3 mm, a moisture content of 3\%, a tensile strength of 1 pascal, and a drug release rate of 90\%. Conclusion: The study demonstrates the successful development and characterization of a novel herbal transdermal patch containing mustard oil and ginger extract for arthritis management. Despite challenges with water-extracted ginger and lower efficacy of the alcohol extract, the oil-based ginger extract showed promising results. The formulated transdermal patch exhibited favourable drug release characteristics and can potentially offer an effective therapeutic option for arthritis patients.

}, keywords = {Anti-arthritic Activity, Docking study, Ginger-mustard extraction, Transdermal patches}, doi = {10.5530/pres.16.4.107}, author = {Arpitha Jayatheertha Lokapur and Vedamurthy Joshi} } @article {637, title = {Anti-arthritic Activity of Root Bark of Oroxylum Indicum (L.) Vent Against Adjuvant-induced Arthritis}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = {121-128}, type = {Original Article }, chapter = {121}, abstract = {

Background:Oroxylum indicum\ (Bignoniaceae) also known as Sonapatha is an indigenous medicinal plant widely used in Ayurvedic medicine for over thousands of years. It is an active ingredient of well-known Ayurvedic formulations such as Chyawanprash and Dasamula. Root bark of this plant has tonic and astringent properties and it is also used in rheumatism.\ Objective:\ The present investigation was carried out to evaluate the anti-arthritic activity of different extracts of root bark of\ Oroxylum indicum\ against adjuvant - induced arthritis in rats.\ Materials and Methods:\ Male Wistar rats were used in this study. Arthritis was induced by injecting 0.1 ml Freund{\textquoteright}s complete adjuvant intra-dermally into the left hind paw of the rats. The paw volume, hematological, biochemical, radiographic and histopathological aspects were evaluated.\ Results:\ The relative percentage inhibition potential of paw volume in rats treated with various extracts of\ Oroxylum indicum\ was found to be ethyl acetate extract (67.69\%) \>chloroform extract (64.61\%) \>n-butanol extract (58.46\%) respectively. The hematological parameters like RBC count, hemoglobin content showed significant increase while there was a significant decrease in total WBC count and ESR in all the groups of animals pretreated with root bark extracts. The biochemical parameters such as catalase, glutathione contents showed a significant increase while the lipid peroxide and Cathepsin-D content decreased significantly only in case of ethyl acetate pretreated rats when compared to others.\ Conclusion:\ The present study suggests that the chloroform, ethyl acetate and n-butanol extracts of root bark of\ Oroxylum indicum\ exhibit anti-arthritic activity. The order of activity of extracts was found to be ethyl acetate \>chloroform \>n-butanol respectively.

}, keywords = {Anti-arthritic Activity, Biochemical parameters, Freund's Complete Adjuvant, Histopathology, Oroxylum indicum}, doi = { 10.4103/0974-8490.110543}, author = {Mamatha Karnati and Rodda H Chandra and Ciddi Veeresham and Bookya Kishan} }