@article {1170, title = {Plant-Derived Selected Bioactive Saponins and Tannins: An Overview of their Multi-Target Mechanisms and Diverse Biological Activities}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {October 2023}, pages = {623-635}, type = {Review Article}, chapter = {623}, abstract = {

An extensive variety of ailments have been treated using medicinal herbs for ages. Recent research has revealed that many of these plants possess multiple therapeutic activities, rendering them interesting candidates for the creation of novel medicines. This review examines the current state of knowledge regarding the multi targeted activities of medicinal plants, including their potential for treating multiple diseases like anti-inflammatory, anti-microbial, anti-hyperglycaemic and anti-cancer activities, their ability to modulate multiple pathways, enzymes, genes and proteins. Finally, the review highlights the potential of naturally derived substances from plant material, for the development of multitargeted drugs and suggests strategies for further research. The multi-target activities will be thoroughly explored in this review of ginsenosides, platycodon D, dioscin, soyasaponins and aescin were chosen as saponins, whereas methyl gallate, chebulinic acid, tannic acid, theaflavin and punicalagins were chosen as tannins. This overview gives a brief history of the isolated natural compounds, their structures, multi-target activity, and their suggested mechanisms of action.

}, keywords = {Bioactive compounds, Biological activities, Medicinal plants, Multi targets, saponins, Tannins}, doi = {10.5530/pres.15.4.066}, author = {Dudday Venkata Vyshnavi and Sunkara Sivananda Swaroop and Akkiraju Sudheer and Somasekhar Reddy Kanala and Ramavath Muralidhar Naik and Onamala Varalakshmi} } @article {549, title = {Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract}, journal = {Pharmacognosy Research}, volume = {9}, year = {2017}, month = {December 2017}, pages = {s23-s26}, type = {Original Article}, chapter = {s26}, abstract = {

Background: Indian traditional system of medicine uses Pithecellobium dulce for the treatment of diabetes mellitus. Objectives: This study aims to develop an extract rich in saponins derived from seeds of the plant and to evaluate its antihyperglycemic potential in vitro and in vivo. Materials and Methods: Defatted seeds were extracted with methanol and processed to afford saponin-enriched fraction (Pithecellobium dulce saponin-enriched fraction [PDSEF]). This fraction was evaluated for its potential to inhibit enzymes such as α-glucosidase and α-amylase, in vitro. The fraction was subjected to oral toxicity study followed by in vivo sucrose tolerance test. An analytical high-performance liquid chromatography method was developed for fingerprinting of the fraction. Results: The method adopted for enrichment of saponins was robust enough to enrich saponin content to 96.37\% {\textpm}1.21\% w/w. PDSEF displayed superior inhibition of enzymes (α-glucosidase and α-amylase with IC50 of 5.12 {\textpm} 0.15 {\textmu}g/ml and 17.28 {\textpm} 0.23 {\textmu}g/ml, respectively) compared to acarbose. It was found to be safe in mice up to 2000 mg/kg and significantly prevented blood glucose level in sucrose tolerance test by inhibiting enzymes responsible for hydrolysis of sucrose. Conclusion: PDSEF displayed excellent antihyperglycemic activity in vitro and in vivo and should be evaluated further to develop it as a promising drug for the management of diabetes mellitus.

}, keywords = {Antihyperglycemic, Pithecellobium dulce, saponins, α-amylase, α-glucosidase}, doi = {10.4103/pr.pr_18_17}, author = {Mahesh Kumar and Jeyabalan Govindrajan and Narendra Kumar Nyola} }