@article {1257, title = {A Comprehensive Review of Ethnomedicinal, Phytochemical and Pharmacological Activity Profile of Achyranthes aspera}, journal = {Pharmacognosy Research}, volume = {16}, year = {2024}, month = {June 2024}, pages = {472-482}, type = {Review Article}, chapter = {472}, abstract = {

For centuries, humans have harnessed the healing properties of plants to address diverse health conditions. Ancient systems like Ayurveda and Unani medicine hold a rich repository of knowledge extolling the virtues of herbal remedies. Achyranthes aspera, one prolific native herbaceous plant in the South America, Asia and Africa often prospers as one common weed. Its many applications in traditional medicine for treating various diseases are at the heart of this global research. Achyranthes aspera is diverse many chemical ingredients, including terpenoids, alkaloids, steroids, saponins and flavonoids. This paper provides a thorough examination and elucidation of the phytochemical composition across different parts of Achyranthes aspera, delving into its traditional uses and expounding upon its pharmacological properties.

}, keywords = {Achyranthes aspera, Anti- microbial activity, anti-inflammatory activity, anti-oxidant, Antidiabetic activity}, doi = {10.5530/pres.16.3.57}, author = {Nem Kumar Jain and Shubham Anand and Priyanka Keshri and Santosh Kumar and Akshay Singh Sengar and Manoj Kumar Bajhaiya and Devendra Dhanorya and Sapna Yadav and Hema Katra and Sajal Mishra} } @article {1085, title = {Chemistry and Pharmacology of Honey}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {October 2022}, pages = {356-359}, type = {Review Article}, chapter = {356}, abstract = {

Honey which is obtained from Apis mellifera has wide uses due to its chemical constituents present in it. World Wide honey is used for nutritious and medicinal purposes. The review would give the platform to the readers, researchers, scholars to have clear view of the chemical components, its probable mechanism, pharmacological activity and comparison of its ancient uses. Apart from pharmacological, nutritional and non-nutritional components its side effects are also discussed. This review would be an insight for the researchers in the field of medicine.

}, keywords = {Adverse effects, anti-oxidant, Honey, Non-nutritional, Nutritional, Pharmacological}, doi = {10.5530/pres.14.4.53}, author = {Kamal Shah and Sumit Chhabra and Nagendra Singh Chauhan} } @article {484, title = {Characterization of Anticancer Principles of Celosia argentea (Amaranthaceae)}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {February 2016}, pages = {97-104}, type = {Original Article}, chapter = {97}, abstract = {

Background: An Indian origin, Celosia argentea is a weed growing during rainy season traditionally claimed for treating several ailments. Early researches on C. argentea were focused on the anti-cancer screening of seeds, with few reports on aerial parts. Objective: To isolate and characterize bioactive compounds of aerial parts of C. argentea and evaluate their anticancer potential. Materials and Methods: The methanolic aerial part extract was fractionated on column chromatography using chloroform: methanol mixture. The fractions; 80:20 and 95:5 were purified on MCI-HP20 HPLC column. Chromatographically pure compounds were pooled, concentrated and characterized spectroscopically. The compounds were further screened for antioxidant and cytotoxic potential. Results: Isolated compounds were confirmed as: (1) Luteolin-7-O-glucoside and (2) phenolic, 1-(4-hydroxy- 2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione. Both exhibited significant antioxidant potential with IC50 values of 20.80 and 21.30 μg/ml for 2,2-diphenyl-1-picrylhydrazyl assay (***P \< 0.001) and significant Trolox equivalent antioxidant capacity (TEAC) values for 2,2{\textquoteright}-azino-bis(3- ethylbenzthiazoline-6-sulphonic acid) (*P \< 0.05) and ferric reducing antioxidant potential assay (****P \< 0.0001). In 3(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl-tetrazoliumbromide assay, Compound 1 and 2 showed potent cytotoxicity against SiHa, HCT, MCF-7 cancer cell lines at 20 μg/ml (****P \< 0.0001) and 18 μg/ml (**P \< 0.01), respectively, without affecting the normal Vero cells. Both compounds enabled maximum reduction in cell viability at 50 μg/ml against HT-29 (***P \< 0.001) and MCF-7 cell lines (**P \< 0.01) in try pan blue viability assay. Apoptosis occurred at concentrations of 47.33 {\textpm} 0.8 μg/ml and 56.28 {\textpm} 1.2 μg/ml for Compound 1 and 35.15 {\textpm} 0.4 μg/ml and 28.05 {\textpm} 0.3 μg/ml for Compound 2 for HT-29 and MCF-7 respectively. Conclusion: A novel anticancer phenolic compound; (1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane- 1,3-dione), isolated from aerial parts of C. argentea was a valuable finding of the research.

}, keywords = {2, 2-diphenyl-1-picrylhydrazylDPPH, 3(4, 5-dimethylthiazol-2- yl)-2, 5-diphenyl-tetrazoliumbromideMTT, anti-oxidant, anticancer, Celosia argentea}, doi = {10.4103/0974-8490.172659}, author = {Rukhsana A. Rub and Manohar J. Pati and Areej A. Siddiqui and Alpana S. Moghe and Nasreen N. Shaikh} }