@article {1344, title = {Green Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {108-114}, type = {Original Article}, chapter = {108}, abstract = {

This study introduces a sustainable method for synthesizing anisotropic Sphaeranthus amaranthoides leaf extract reduced gold nanoparticles (S-GNPs) by utilizing the phenolic compounds present in Sphaeranthus amaranthoides leaf extract. Background: Unlike conventional chemical methods, this eco-friendly approach leverages natural sunlight as a catalyst and hyaluronic acid for stabilization, providing a green, scalable solution. Objectives: The research aims to develop a biocompatible, stable nanoparticle system for targeted cancer drug delivery. Materials and Methods: The nanoparticles were synthesized and characterized using Surface Plasmon Resonance (SPR) and High-Resolution Transmission Electron Microscopy (HRTEM) to confirm size, morphology, and zeta potential. Stability was tested in saline solutions at physiological pH. In vivo toxicity studies were conducted using zebra fish larvae, demonstrating high biocompatibility at concentrations below 100 μg/mL. Conclusion: Dexamethasone-loaded S-GNPs exhibited significant cytotoxicity against THP-1 Acute Monocytic Leukemia cells, underscoring the potential of this eco-friendly synthesis method for cancer therapy applications. These findings highlight the viability of S-GNPs as effective, biocompatible vehicles for targeted drug delivery, presenting a sustainable alternative to conventional nanoparticle systems.

}, keywords = {Anticancer activity, Dexamethasone, Gold nanoparticles, Leaf extract, Sphaeranthus amaranthoides}, doi = {10.5530/pres.20251946}, author = {Iram Shabbir Khan and Swarnalatha Yanamadala and Senthilkumar Chinnaiyan and Narendran Chiterasu and Sidhika Kannan} } @article {396, title = {Isolation and Characterization of Chemopreventive Agent from Sphaeranthus amaranthoides Burm F}, journal = {Pharmacognosy Research}, volume = {8}, year = {2016}, month = {December 2015}, pages = {61-65}, type = {Original Article}, chapter = {61}, abstract = {

Objective: To investigate the in vitro cytotoxic effect and to isolate and characterize a chemopreventive secondary metabolite from Sphaeranthus amaranthoides Burm F (sivakaranthai). Materials and Methods: In vitro cytotoxic effect was carried out by 3 (4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide assay. Different concentrations of the extracts were tested on three different cell lines namely A549, HT29, and MCF7. The chloroform extract was subjected to column chromatography, and the isolated compound was characterized by various spectral methods and by single crystal X-ray crystallography. Results: The concentration that cause 50\% growth inhibition value of chloroform extract was found to be 0.9 and 19 μg/mL against MCF7 and A549 cell lines, respectively. Chloroform extract was subjected to column chromatography for the isolation of phytoconstituent. The structure of the isolated compound was identified by spectroscopic techniques such as infrared, nuclear magnetic resonance, XRD, and mass spectroscopy. On comparison of complete spectral detail of the compound, the proposed structure was identified as chrysosplenol D (a flavonoid). Chrysosplenol D was isolated for the first time from this plant. Conclusion: The chloroform extract had higher cytotoxic effect, and the isolated chrysosplenol D may be responsible for the anti-proliferative effect of the plant.

}, keywords = {3 (4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide assay, Characterization, Chemopreventive agent, Chrysosplenol D, Isolation, Sphaeranthus amaranthoides}, doi = {10.4103/0974-8490.171101}, author = {S. Gayatri and R. Suresh and C. Uma Maheswara Reddy and K. Chitra} }