@article {1456, title = {GC-MS Analysis of Dhanwanthari Taila: Identification of Bioactive Compounds Supporting its Analgesic and Anti-Inflammatory Potential in Chronic Low Back Pain}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {955-960}, type = {Original Article}, chapter = {955}, abstract = {

Background: The scientific validation of traditional Ayurvedic formulations is crucial for integrating them into modern therapeutic practices. Dhanwanthari Taila, a widely used Ayurvedic medicated oil, is traditionally used for pain management, particularly in musculoskeletal disorders like Chronic Low Back Pain (CLBP). Aim and Objectives: This study utilizes Gas Chromatography-Mass Spectrometry (GC-MS) to analyze the chemical composition of Dhanwanthari Taila, aiming to establish correlations between its bioactive compounds and its therapeutic effects in pain relief. Materials and Methods: A sample (100 mL) of Dhanwanthari Taila was procured from KLE GMP certified Ayurveda Pharmacy and subjected to GC-MS analysis using standard analytical protocols to identify its bioactive components. Results and Discussion: The analysis identified key bioactive compounds, including Glycidyl palmitoleate, Oleic acid, 1-Decyne, 3-Tridecene, and Hexadecanoic acid derivatives, which are known for their anti-inflammatory and analgesic properties. The high concentration of Glycidyl palmitoleate suggests its potential contribution to the oil{\textquoteright}s therapeutic efficacy. These findings align with the traditional use of Dhanwanthari Taila in alleviating pain, inflammation, and stiffness, supporting its role in managing CLBP and related conditions. Conclusion: The presence of these bioactive molecules validates the therapeutic application of Dhanwanthari Taila as an effective pain-relieving formulation. Further research is essential to explore its clinical efficacy and potential integration into conventional pain management strategies.

}, keywords = {Analgesic, Anti-inflammatory, Chronic Low Back Pain, Dhanwanthari Taila, GC-MS}, doi = {10.5530/pres.20252192}, author = {Ramesh Shivappa Killedar and Pradeep Shahjirao Shindhe and Vijay Kage and Raj Joshi} } @article {1482, title = {Identification of Bioactive Metabolites in Bhadrikadi Ghrita: A Phytochemical and GC-MS Approach to Investigating Analgesic and Anti-inflammatory Properties}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {August 2025}, pages = {1241-1252}, type = {Original Article}, chapter = {1241}, abstract = {

Background: Ayurveda healthcare system holds considerable reputation in today{\textquoteright}s era. Treatises of Ayurveda explained numerous formulations with their potential therapeutic benefits but their global acceptance is poor due to the lack of scientific validity. Bhadrikadi Ghrita is one such formulation indicated for Marmakshat Ruja. Thus, there is an obvious need to overcome this lacuna by subjecting these medicines to thorough tests in light of modern research about their pharmacological, pharmacokinetic, and toxicity standards. Aim: The present study employs Gas Chromatography-Mass Spectrometry (GC-MS) analysis to investigate pain-relieving Ayurvedic Ghee, Bhadrikadi Ghrita, aiming to establish correlations between its medicinal activity and the biomolecules it contains. Materials and Methods: Bhadrikadi Ghrita was prepared according to Ayurvedic standards and subjected to GC-MS analysis. The detected compounds were identified by comparing their mass spectra with standard libraries and previous literature. A functional classification of the bioactive compounds was conducted to understand their potential therapeutic implications. Results and Discussion: The resulting profile revealed the presence of diverse array of bioactive compounds, including fatty acids, terpenoids, phenolic derivatives, and sterols. Notable compounds included linoleic acid, oleic acid, squalene, and curcumene. These constituents are associated with anti-inflammatory, antioxidant, antimicrobial, and neuroprotective properties. Conclusion: The identification of these bioactive compounds supports the therapeutic potentials of Bhadrikadi Ghrita as an effective pain-relieving ghee in Marmakshat Ruja, warranting further pharmacological and clinical studies.

}, keywords = {Bhadrikadi Ghrita, Bioactive Metabolites, GC-MS, Marmakshat Ruja, Phytochemical analysis, Traditional medicine}, doi = {10.5530/pres.20252163}, author = {Raj Joshi and Santosh Mudakappagol and Adithya Anil} }