@article {1371, title = {Analgesic and Anti-inflammatory Properties of Oxalis dehradunensis Raizada in Rats}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {185-191}, type = {Original Article}, chapter = {185}, abstract = {

Background: Inflammation is a complex biological response that plays a key role in the body{\textquoteright}s defence mechanisms against various injuries and infections. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are widely used to treat pain and inflammatory conditions, but their long-term use is associated with adverse effects. Therefore, there is a need to explore alternative therapies for pain and inflammation management. Plant extracts are an excellent source of natural compounds that possess anti-inflammatory and analgesic activity. Objectives: The study aims to investigate the anti-inflammatory and analgesic potential of ethanolic extract of Oxalis dehradunensis leaf powder. Materials and Methods: The extraction of the plant part was carried out using ethanol in Soxhlet apparatus. Preliminary phytochemical screening of the ethanolic extract was performed to check the phytoconstituents. In the in vivo study, inflammation was induced in albino Wistar rats by causing hind paw oedema using carrageenan. Hot plate and Tail flick model was used to evaluate analgesic activity. Diclofenac sodium was used as a standard for inflammatory and analgesic activity. Results: The findings suggest that ethanolic leaf extract of Oxalis dehradunensis showed the presence of flavonoids, carbohydrates, phenols and tannins. At doses of 200 and 400 mg/kg body weight, the ethanolic leaf extract of Oxalis dehradunensis exhibited significant anti-inflammatory activity against carrageenan-induced paw edema following injection. In analgesic activity (Hot plate and Tail flick model) the results showed that Oxalis dehradunensis Raizada extracts at doses of 200 and 400 mg/kg increased the reaction latency time in both tests, indicating a significant antinociceptive effect. Conclusion: The ethanolic leaves extract of Oxalis dehradunensis exhibited significant anti-inflammatory and analgesic effects.

}, keywords = {Analgesia, Flavonoids, Inflammation, Oxalis dehradunensis, Polyphenols}, doi = {10.5530/pres.20251985}, author = {Sudhakar Kaushik and Priyanka Bhandari and Amisha Bhandari and Bhawana Bhatt and Heena Mittal and Assem Babbar} } @article {1452, title = {Spectrophotometric SPF Assessment and Phytochemical Screening of Pleiogynium cerasiferum Leaf Extracts}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {914-919}, type = {Original Article}, chapter = {914}, abstract = {

Background: Concerns over the environmental impact and potential health risks associated with synthetic Ultraviolet (UV) filters have intensified the search for natural, eco-friendly alternatives in sun protection formulations. In this study, we investigated the sun protection factor (SPF) of Pleiogynium cerasiferum leaves extracts using ethanol, aqueous and Petroleum ether as extraction solvents to assess their potential as natural UV-absorbing agents. Materials and Methods: Pleiogynium cerasiferum leaves extracts were analyzed using UV spectrophotometry via the Mansur equation, measuring absorbance across the UVB spectrum. Preliminary phytochemical analysis was conducted to identify major bioactive compounds. These analyses provided insights into the extracts potential bioactivity. Results: The preliminary phytochemical analysis of Pleiogynium cerasiferum extracts confirmed the presence of alkaloids, carbohydrates, flavonoids, glycosides, tannins, saponins, and phenols. Additionally, these extracts exhibited significant sun-protective properties. The ethanol extract demonstrated a Sun Protection Factor (SPF) value of 3.92, whereas the aqueous extract and petroleum ether extract showed SPF values of 1.10 and 0.36, respectively. Conclusion: The significant SPF values observed in Pleiogynium cerasiferum extracts highlight their potential as valuable additions to sunscreen formulations, enhancing sun protection while reducing dependence on synthetic UV filters. Furthermore, the incorporation of these natural extracts aligns with the growing demand for sustainable skincare solutions, offering benefits for both environmental safety and consumer health. These findings indicate that the extraction solvent plays a crucial role in isolating bioactive compounds responsible for UV absorption. The study highlights the potential of Pleiogynium cerasiferum as a natural source of photoprotective agents, warranting further investigation into its formulation for sunscreen applications.

}, keywords = {In vitro activity, Mansur equation, Photo damage, Pleiogynium cerasiferum, Sunscreens, Ultraviolet (UV) radiation}, doi = {10.5530/pres.20252165}, author = {Bhawana Bhatt and Sudhakar Kaushik and Heena Mittal and Lata Sati} }