@article {1346, title = {Diabetes: Exploring the Intersection of Metabolic Disorders, Lifestyle Factors and Herbal Remedies: A Review}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {January 2025}, pages = {11-17}, type = {Review Article}, chapter = {11}, abstract = {

A chronic metabolic disorder, Diabetes mellitus significantly poses a health challenge globally. The escalating prevalence of diabetes, coupled with concerns regarding the side effects of conventional antidiabetic drugs, has spurred increased interest in exploring alternative therapeutic approaches. Herbal medicines, deeply rooted in traditional healing practices, have emerged as promising candidates for managing diabetes. The objective of this review is to optimise the current scientific literature on herbal medicines employed as antidiabetic agents. The review encompasses an in-depth analysis of diverse medicinal plants which have potential for management of T2DM. The potential of these herbal remedies in improving insulin sensitivity, modulating glucose metabolism and mitigating diabetes-related complications are established. Furthermore, the review critically examines clinical studies evaluating the potency and safe usage of herbal medicines in diabetic populations. Emphasis is placed on highlighting the need for further research and addressing challenges associated with standardization and quality check of herbal preparation. The integration of herbal medicines into mainstream diabetes care is explored, considering the potential for synergistic use with conventional therapies. In nutshell; this review consolidates existing knowledge, sheds light on promising avenues for future research and emphasizes the significance of herbal medicines in the quest for effective, safe and sustainable antidiabetic interventions. The wealth of traditional wisdom encapsulated in these natural remedies presents a valuable resource in the pursuit of novel therapeutic strategies for diabetes management.

}, keywords = {Antidiabetic activity, Diabetes, Herbal plants, Metabolic Disorder, T2DM}, doi = {10.5530/pres.20251951}, url = {https://readarticle.org/lensarticle/diabetes-exploring-the-intersection-of-metabolic-disorders-lifestyle-factors-and-herbal-remedies-a-review/}, author = {Shweta Bhandari and Rahul Trivedi and Rajesh A. Maheshwari and Swetaba Besh and Maitri Mahant and Sapana Patil and Vishal Garg and Ram Singh} } @article {1428, title = {Flavonoids: A Class of Polyphenols with Diverse Anti-inflammatory Activities and Mechanisms}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {755-768}, type = {Review Article}, chapter = {755}, abstract = {

The impact of our dietary choices on our overall well-being is widely recognized in the field of nutrition. The influence of diet on human metabolism is widely recognized, by the consumption of an abundance of fresh fruits and vegetables being universally acknowledged as highly helpful. A number of ways have been proposed to understand the potential health advantages of incorporating fruits and vegetables into the food that one consumes. Right now, flavonoids have become prominent components in various products, such as nutritional and health foods, dietary supplements, and cosmetics as well. Glycosides are often encountered in nature, which include flavonoids. The complexity of flavonoids is made easier by the presence of sugar groups in their structure, which leads to their limited absorption over the gut wall. Flavonoid glycosides have the capacity of passing through the human digestive system and are thereafter metabolized in the colon by microbes that possess the capability to break down the glycosidic link. The above process promotes the production of flavonoid aglycones, which are then taken in by the distal end of the digestive system. Different experimental studies have shown the potential anti-inflammatory effects of flavonoid compounds. This review focuses on the influence of dietary flavonoids on signaling pathways related to inflammation, which subsequently impacts the formation of inflammatory mediators. The imperative involvement of flavonoids in preventing the growth of inflammation is highlighted to provide helpful perspectives.

}, keywords = {Flavonoids, Inflammation, Plant secondary metabolites}, doi = {10.5530/pres.20252237}, author = {Divya Jashvantkumar Kanojiya and Maitri Mahant and Sweta Besh and Sarika Parekh and Ghanshyam Parmar} } @article {1505, title = {Secondary Metabolite as Therapeutic Agents with Significant Highlight on Terpenoids}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {September 2025}, pages = {1140-1147}, type = {Review Article}, chapter = {1140}, abstract = {

The belief that plants possess biologically active compounds with healing properties beneficial for treating various health conditions has endured since ancient times. The therapeutic importance of these plants highlights their vast potential for the discovery and development of new pharmaceuticals, attributed to their chemical constituents that positively impact human health. Numerous naturally occurring phytochemicals, both dietary and non-dietary, have demonstrated significant potential in preventing and treating various diseases. Secondary metabolites are organic compounds naturally produced by plants, microbes, and certain animals, serving vital roles that extend beyond essential survival functions. Compounds such as alkaloids, flavonoids, terpenoids, and phenolics have garnered considerable interest due to their varied chemical structures and powerful biological effects. They demonstrate a broad spectrum of pharmacological properties, including antidiabetics, anticancer, anti-inflammatory and antioxidant as well as antimalarial, which make them important therapeutic agents in contemporary medicine. Terpenoids, or terpenes, form the largest group of natural compounds and are known for their biological activities, making them valuable in the treatment of human diseases. In the present work we have highlight the potential therapeutic benefit of terpenoids. Among the secondary metabolites terpenoids having more potential to be therapeutic agents for various disorders. Over the past two decades, bioprospecting natural products from the marine environment has led to the discovery of hundreds of terpenoids with unique structures and promising bioactivities, with many more yet to be uncovered.

}, keywords = {anticancer, Antidiabetic, Antimalarial, Antioxidant, Secondary metabolites, Terpenoids}, doi = {10.5530/pres.20252366}, author = {Sarika Sapan Parekh and Rahul Trivedi and Divya Kanojia and Sweta Ba Besh and Maitri Mahant and Ghanshyam Ratilal Parmar} }